ReviewFrontiers in neuroscience2014
Does functional MRI detect activation in white matter? A review of emerging evidence, issues, and future directions.
Review in Frontiers in neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 149 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
149 citing papers in PubMed.
- Effect of Cognitive Training in Fully Immersive Virtual Reality on Visuospatial Function and Frontal-Occipital Functional Connectivity in Predementia: Randomized Controlled Trial.Journal of medical Internet research · 2021Trial
- Ambiguity tolerance and resting-state functional connectivity: A preregistered conceptual replication in a Japanese sample.Neuroimage. Reports · 2026Article
- A Distinct Second Spectral Peak in White Matter BOLD Signals: Mathematical Modeling, Spatial Distribution and Age-Related Evolution.Research square · 2026Article
- Electrophysiological features of signals recorded from white matter.bioRxiv : the preprint server for biology · 2026Article
- White-Matter BOLD Encoding Beyond Marginal Connectivity.bioRxiv : the preprint server for biology · 2026Article
- Disrupted white matter functional connectivity in post-stroke cognitive impairment: Insights from resting-state fMRI.Brain imaging and behavior · 2026Article
- Mapping the functional connectome between grey matter and white matter.Communications biology · 2026Article
- Complementarity of BOLD and ADC-fMRI in Mapping Brain Visual Processing in the Rat.NMR in biomedicine · 2026Article
- Voxel-mirrored homotopic connectivity in upper motor neuron-dominant amyotrophic lateral sclerosis is associated with different spread directions.Brain imaging and behavior · 2026Article
- Age-stratified multimodal MRI and machine learning to explore autism-related brain characteristics in youth.Frontiers in psychiatry · 2026Article
- Beyond scaling: how brains reorganize to support higher intelligence.Frontiers in systems neuroscience · 2026Article
- Learning image derived PDE-phenotypes from fMRI data.Brain informatics · 2025Article
- Early brain changes in Lyme disease are associated with clinical outcomes.Brain, behavior, & immunity - health · 2025Article
- GWM-HFN, a Gray-White Matter heterogeneous fusion network for functional connectomes.Communications biology · 2025Article
- Cortical modulation of resting state BOLD signals in white matter.Scientific reports · 2025Article
- Functional contrast across the gray-white matter boundary.Nature communications · 2025Article
- A multiplex of connectome trajectories enables several connectivity patterns in parallel.eLife · 2025Article
- Spine-Prints: Transposing Brain Fingerprints to the Spinal Cord.bioRxiv : the preprint server for biology · 2025Article
- Mapping grey and white matter activity in the human brain with isotropic ADC-fMRI.Nature communications · 2025Article
- Myelination selectively modulates BOLD signal in white matter.Research square · 2025Article
89 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Functional magnetic resonance imaging (fMRI) is a non-invasive technique that allows for visualization of activated brain regions. Until recently, fMRI studies have focused on gray matter. There are two main reasons white matter fMRI remains controversial: (1) the blood oxygen level dependent (BOLD) fMRI signal depends on cerebral blood flow and volume, which are lower in white matter than gray matter and (2) fMRI signal has been associated with post-synaptic potentials (mainly localized in gray matter) as opposed to action potentials (the primary type of neural activity in white matter). Despite these observations, there is no direct evidence against measuring fMRI activation in white matter and reports of fMRI activation in white matter continue to increase. The questions underlying white matter fMRI activation are important. White matter fMRI activation has the potential to greatly expand the breadth of brain connectivity research, as well as improve the assessment and diagnosis of white matter and connectivity disorders. The current review provides an overview of the motivation to investigate white matter fMRI activation, as well as the published evidence of this phenomenon. We speculate on possible neurophysiologic bases of white matter fMRI signals, and discuss potential explanations for why reports of white matter fMRI activation are relatively scarce. We end with a discussion of future basic and clinical research directions in the study of white matter fMRI.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.