Evidence map›Paper›PMID 25152593›Full record

ArticleWorld journal of gastroenterology2014

Perinodular ductular reaction/epithelial cell adhesion molecule loss in small hepatic nodules.

Qin Zhang, Chuan-Shan Zhang, Qi Xin, Zhe Ma, Gui-Qiu Liu, Bing-Bing Liu, Feng-Mei Wang, Ying-Tang Gao, Zhi Du

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Qin ZhangQin Zhang, Chuan-Shan Zhang, Qi Xin, Zhe Ma, Gui-Qiu Liu, Bing-Bing Liu, Department of Pathology, the Third Central Hospital of Tianjin Medical University, Tianjin 300170, China.
Chuan-Shan ZhangQin Zhang, Chuan-Shan Zhang, Qi Xin, Zhe Ma, Gui-Qiu Liu, Bing-Bing Liu, Department of Pathology, the Third Central Hospital of Tianjin Medical University, Tianjin 300170, China.
Qi XinQin Zhang, Chuan-Shan Zhang, Qi Xin, Zhe Ma, Gui-Qiu Liu, Bing-Bing Liu, Department of Pathology, the Third Central Hospital of Tianjin Medical University, Tianjin 300170, China.
Zhe MaQin Zhang, Chuan-Shan Zhang, Qi Xin, Zhe Ma, Gui-Qiu Liu, Bing-Bing Liu, Department of Pathology, the Third Central Hospital of Tianjin Medical University, Tianjin 300170, China.
Gui-Qiu LiuQin Zhang, Chuan-Shan Zhang, Qi Xin, Zhe Ma, Gui-Qiu Liu, Bing-Bing Liu, Department of Pathology, the Third Central Hospital of Tianjin Medical University, Tianjin 300170, China.
Bing-Bing LiuQin Zhang, Chuan-Shan Zhang, Qi Xin, Zhe Ma, Gui-Qiu Liu, Bing-Bing Liu, Department of Pathology, the Third Central Hospital of Tianjin Medical University, Tianjin 300170, China.
Feng-Mei WangQin Zhang, Chuan-Shan Zhang, Qi Xin, Zhe Ma, Gui-Qiu Liu, Bing-Bing Liu, Department of Pathology, the Third Central Hospital of Tianjin Medical University, Tianjin 300170, China.
Ying-Tang GaoQin Zhang, Chuan-Shan Zhang, Qi Xin, Zhe Ma, Gui-Qiu Liu, Bing-Bing Liu, Department of Pathology, the Third Central Hospital of Tianjin Medical University, Tianjin 300170, China.
Zhi DuQin Zhang, Chuan-Shan Zhang, Qi Xin, Zhe Ma, Gui-Qiu Liu, Bing-Bing Liu, Department of Pathology, the Third Central Hospital of Tianjin Medical University, Tianjin 300170, China.
Tianjin Third Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate if loss of epithelial cell adhesion molecule (EpCAM) is associated with microinvasion in hepatocellular carcinomas (HCCs) in the presence of chronic hepatitis B.

methodsThe expression of EpCAM, cytokeratin 7 (CK7) and CK19 in 112 hepatic nodules was studied, including 20 HCCs with nodules ≤ 3 cm, 26 HCCs with nodules > 3 cm, 20 high-grade dysplastic nodules, 26 cirrhotic, large regenerative nodules and 20 cases of cirrhosis.

resultsMembranes of ductular reaction (DR) hepatobiliary cells, interlobular bile duct and some hepatic cells were positive for EpCAM expression. Active expression of DR/EpCAM was observed in the majority of noninvasive nodules (50/66, 75.76%); however, expression was absent in the major area of invasion in HCCs (42/46, 91.30%). DR/EpCAM loss in HCCs ≤ 3 cm was higher than in high-grade dysplastic nodules (HGDNs) (P < 0.05), cirrhotic, large regenerative nodules and cirrhosis (P < 0.01). Furthermore, patients (20 HCCs ≤ 3 cm, 26 HCCs > 3 cm, 20 HGDNs) with DR/EpCAM expression had a higher overall survival rate (P < 0.01) and lower early recurrence rate (P < 0.01). DR/EpCAM expression showed a close relationship with DR/CK7 and DR/CK19 expression (P < 0.01). The area under the receiver operating characteristic (ROC) curve of DR/EpCAM was similar to that of DR/CK7 and DR/CK19 (P > 0.05). The diagnostic specificity and diagnostic accuracy were both increased when DR/EpCAM, DR/CK7 and DR/CK19 were combined (P < 0.01).

conclusionDR/EpCAM loss may be a useful marker for determining microinvasion in HCCs ≤ 3 cm, but also for predicting prognosis.

Indexed as

Antigens, NeoplasmArea Under CurveBile Ducts, IntrahepaticBiomarkers, TumorCarcinoma, HepatocellularCell Adhesion MoleculesDisease-Free SurvivalDown-RegulationEpithelial Cell Adhesion MoleculeFemaleHepatitis B, ChronicHumansImmunohistochemistryKaplan-Meier EstimateKeratin-19Keratin-7Antigens, NeoplasmBiomarkers, TumorCell Adhesion MoleculesEPCAM protein, humanEpithelial Cell Adhesion MoleculeKeratin-19Keratin-7KRT7 protein, humanDifferential diagnosisDuctular reactionEpithelial cell adhesion moleculeHepatocellular carcinomasMicroinvasionSmall hepatic nodule

Identifiers

PMID25152593
PMCPMC4138470
OpenAlexW2094920612

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.