ArticleWorld journal of gastroenterology2014
Oxytocin decreases colonic motility of cold water stressed rats via oxytocin receptors.
Article in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- Animal Models of Slow-Transit Constipation: Current Progress, Limitations, and Future Perspectives.Digestive diseases and sciences · 2026Review
- Protective Effects of Oxytocin on Experimental Colitis: Modulation of Cytokines, Oxidative Stress, and Caspase-3 Activity.Medicina (Kaunas, Lithuania) · 2026Article
- Cold and hot consumption and health outcomes among US Asian and White populations.The British journal of nutrition · 2025Article
- Variability in Oxytocin Blood Levels in Rats: A Review and Experimental Insights.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025Article
- Article
- Oxytocin/Oxytocin Receptor Signalling in the Gastrointestinal System: Mechanisms and Therapeutic Potential.International journal of molecular sciences · 2024Review
- Mechanism of Oxytocin-Induced Contraction in Rat Gastric Circular Smooth Muscle.International journal of molecular sciences · 2022Article
- Specific Changes in the Mammalian Gut Microbiome as a Biomarker for Oxytocin-Induced Behavioral Changes.Microorganisms · 2021Article
- The New Frontier in Oxytocin Physiology: The Oxytonic Contraction.International journal of molecular sciences · 2020Review
- Risk Factors of Prolonged Nausea and Vomiting During Pregnancy.Risk management and healthcare policy · 2020Article
- Intranasal Administration of Oxytocin Attenuates Stress Responses Following Chronic Complicated Stress in Rats.Journal of neurogastroenterology and motility · 2019Article
- Inhibitory effect of the Kampo medicinal formula Yokukansan on acute stress-induced defecation in rats.Neuropsychiatric disease and treatment · 2018Article
- Electroacupuncture at acupoint ST 37(Shangjuxu) improves function of the enteric nervous system in a novel mouse constipation model.BMC complementary and alternative medicine · 2016Article
- Development of a novel mouse constipation model.World journal of gastroenterology · 2016Article
- A non-invasive method to evaluate gastrointestinal transit behavior in rat.Journal of pharmacological and toxicological methodsArticle
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate whether cold water intake into the stomach affects colonic motility and the involvement of the oxytocin-oxytocin receptor pathway in rats.
methodsFemale Sprague Dawley rats were used and some of them were ovariectomized. The rats were subjected to gastric instillation with cold (0-4 °C, cold group) or room temperature (20-25 °C, control group) saline for 14 consecutive days. Colon transit was determined with a bead inserted into the colon. Colonic longitudinal muscle strips were prepared to investigate the response to oxytocin in vitro. Plasma concentration of oxytocin was detected by ELISA. Oxytocin receptor expression was investigated by Western blot analysis. Immunohistochemistry was used to locate oxytocin receptors.
resultsColon transit was slower in the cold group than in the control group (P < 0.05). Colonic smooth muscle contractile response to oxytocin decreased, and the inhibitory effect of oxytocin on muscle contractility was enhanced by cold water intake (0.69 ± 0.08 vs 0.88 ± 0.16, P < 0.05). Atosiban and tetrodotoxin inhibited the effect of oxytocin on colonic motility. Oxytocin receptors were located in the myenteric plexus, and their expression was up-regulated in the cold group (P < 0.05). Cold water intake increased blood concentration of oxytocin, but this effect was attenuated in ovariectomized rats (286.99 ± 83.72 pg/mL vs 100.56 ± 92.71 pg/mL, P < 0.05). However, in ovariectomized rats, estradiol treatment increased blood oxytocin, and the response of colonic muscle strips to oxytocin was attenuated.
conclusionCold water intake inhibits colonic motility partially through oxytocin-oxytocin receptor signaling in the myenteric nervous system pathway, which is estrogen dependent.
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