Evidence map›Paper›PMID 25152476›Full record

Trial reportThe Journal of thoracic and cardiovascular surgery2014

Myocardial viability and impact of surgical ventricular reconstruction on outcomes of patients with severe left ventricular dysfunction undergoing coronary artery bypass surgery: results of the Surgical Treatment for Ischemic Heart Failure trial.

Thomas A Holly, Robert O Bonow, J Malcolm O Arnold, Jae K Oh, Padmini Varadarajan, Gerald M Pohost, Haissam Haddad, Robert H Jones, Eric J Velazquez, Bozena Birkenfeld and 8 more

Open access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of thoracic and cardiovascular surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. European Association of Cardiovascular Imaging survey on imaging for myocardial viability.European heart journal. Imaging methods and practice · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Observational
  7. Article
  8. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 14 institutions in 5 countries.

Thomas A HollyNorthwestern University, Chicago, Ill. Electronic address: t-holly@northwestern.edu.
Robert O BonowNorthwestern University, Chicago, Ill.
J Malcolm O ArnoldUniversity of Western Ontario, London, Ontario, Canada.
Jae K OhMayo Clinic, Rochester, Minn.
Padmini VaradarajanLoma Linda University, Loma Linda, Calif.
Gerald M PohostUniversity of Southern California, Los Angeles, Calif.
Haissam HaddadOttawa Heart Institute, Ottawa, Ontario, Canada.
Robert H JonesDuke University, Durham, NC.
Eric J VelazquezDuke University, Durham, NC.
Bozena BirkenfeldDepartment of Nuclear Medicine PUM, Szczecin, Poland.
Federico M AschMedStar Washington Hospital Center, Washington, DC.
Marcin MalinowskiMedical University of Silesia, Katowice, Poland.
Rodrigo BarrettoInstituto Dante Pazzanese de Cardiologia, Sao Paulo, Brazil.
Renato A K KalilInstituto de Cardiologia, Porto Alegre, Brazil.
Daniel S BermanCedars-Sinai Medical Center, Los Angeles, Calif.
Jie-Lena SunDuke University, Durham, NC.
Kerry L LeeDuke University, Durham, NC.
Julio A PanzaWestchester Medical Center, Valhalla, NY.
Duke University · USCedars-Sinai Medical Center · USFundação Universitária de Cardiologia · BRInstituto Dante Pazzanese de Cardiologia · BRLoma Linda University · USMayo Clinic in Arizona · USMedical University of Silesia · PLMedStar Washington Hospital Center · USNorthwestern University · PHNorthwestern University · USOttawa Heart Institute · CAUniversity of Southern California · USWestchester Medical Center · USWestern University · CA

Funding

STICH Trial-Coordinating CenterU01HL069015 · NHLBI · DUKE UNIVERSITY · PI JONES, ROBERT H · 2002 to 2011
$27.3M
STICHESR01HL105853 · NHLBI · DUKE UNIVERSITY · PI AL-KHALIDI, HUSSEIN · 2011 to 2015
$10.2M
STICH Trial-Statistical and Data Coordinatiing CenterU01HL069013 · NHLBI · DUKE UNIVERSITY · PI LEE, KERRY L · 2002 to 2010
$5.0M
STICH Trial Radionuclide Core LaboratoryU01HL069012 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BONOW, ROBERT O · 2002 to 2007
$2.0M
NHLBI NIH HHS R01 HL105853NHLBI NIH HHS R01HL69012NHLBI NIH HHS U01 HL069012NHLBI NIH HHS U01 HL069013NHLBI NIH HHS U01 HL069015NHLBI NIH HHS U01HL69015NHLBI NIH HHS UO1HL69013
6 · The paper itself

Abstract

objectivesIn the Surgical Treatment for Ischemic Heart Failure trial, surgical ventricular reconstruction plus coronary artery bypass surgery was not associated with a reduction in the rate of death or cardiac hospitalization compared with bypass alone. We hypothesized that the absence of viable myocardium identifies patients with coronary artery disease and left ventricular dysfunction who have a greater benefit with coronary artery bypass graft surgery and surgical ventricular reconstruction compared with bypass alone.

methodsMyocardial viability was assessed by single photon computed tomography in 267 of the 1000 patients randomized to bypass or bypass plus surgical ventricular reconstruction in the Surgical Treatment for Ischemic Heart Failure. Myocardial viability was assessed on a per patient basis and regionally according to prespecified criteria.

resultsAt 3 years, there was no difference in mortality or the combined outcome of death or cardiac hospitalization between those with and without viability, and there was no significant interaction between the type of surgery and the global viability status with respect to mortality or death plus cardiac hospitalization. Furthermore, there was no difference in mortality or death plus cardiac hospitalization between those with and without anterior wall or apical scar, and no significant interaction between the presence of scar in these regions and the type of surgery with respect to mortality.

conclusionsIn patients with coronary artery disease and severe regional left ventricular dysfunction, assessment of myocardial viability does not identify patients who will derive a mortality benefit from adding surgical ventricular reconstruction to coronary artery bypass graft surgery.

Indexed as

Coronary Artery BypassPlastic Surgery ProceduresVentricular Function, LeftAgedCardiomyopathiesCoronary Artery DiseaseFemaleHeart FailureHumansKaplan-Meier EstimateMaleMiddle AgedMyocardiumPredictive Value of TestsProportional Hazards ModelsSeverity of Illness Index

Identifiers

PMID25152476
PMCPMC4250319
OpenAlexW2106043422

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.