ArticleGenome biology and evolution2014
Genomic organization, transcriptomic analysis, and functional characterization of avian α- and β-keratins in diverse feather forms.
Article in Genome biology and evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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49 citing papers in PubMed, 75 citations in OpenAlex.
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- Research Progress on the Molecular Mechanism of Poultry Feather Follicle Development.Current issues in molecular biology · 2025Review
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- Skin Appendage Proteins of Tetrapods: Building Blocks of Claws, Feathers, Hair and Other Cornified Epithelial Structures.Animals : an open access journal from MDPI · 2025Review
- Modification of Keratin Integrations and the Associated Morphogenesis in Frizzling Chicken Feathers.Biology · 2024Article
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- Conserved regulatory switches for the transition from natal down to juvenile feather in birds.Nature communications · 2024Article
- Development-Associated Genes of the Epidermal Differentiation Complex (EDC).Journal of developmental biology · 2024Review
- Autofluorescence microscopy as a non-invasive probe to characterize the complex mechanical properties of keratin-based integumentary organs: A feather paradigm.Chinese journal of physics · 2023Article
- Transition from natal downs to juvenile feathers: conserved regulatory switches in Neoaves.Research square · 2023Article
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- The idiosyncratic genome of Korean long-tailed chicken as a valuable genetic resource.iScience · 2023Article
- The Story of the Finest Armor: Developmental Aspects of Reptile Skin.Journal of developmental biology · 2023Review
- Regional specific differentiation of integumentary organs: SATB2 is involved in α- and β-keratin gene cluster switching in the chicken.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Article
- The evolutionary history and mechanistic basis of female ornamentation in a tropical songbird.Evolution; international journal of organic evolution · 2022Article
- Origin and significance of the human DNase repertoire.Scientific reports · 2022Article
- Establishment of a culture model for the prolonged maintenance of chicken feather follicles structure in vitro.PloS one · 2022Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 3 countries.
Funding
Abstract
Feathers are hallmark avian integument appendages, although they were also present on theropods. They are composed of flexible corneous materials made of α- and β-keratins, but their genomic organization and their functional roles in feathers have not been well studied. First, we made an exhaustive search of α- and β-keratin genes in the new chicken genome assembly (Galgal4). Then, using transcriptomic analysis, we studied α- and β-keratin gene expression patterns in five types of feather epidermis. The expression patterns of β-keratin genes were different in different feather types, whereas those of α-keratin genes were less variable. In addition, we obtained extensive α- and β-keratin mRNA in situ hybridization data, showing that α-keratins and β-keratins are preferentially expressed in different parts of the feather components. Together, our data suggest that feather morphological and structural diversity can largely be attributed to differential combinations of α- and β-keratin genes in different intrafeather regions and/or feather types from different body parts. The expression profiles provide new insights into the evolutionary origin and diversification of feathers. Finally, functional analysis using mutant chicken keratin forms based on those found in the human α-keratin mutation database led to abnormal phenotypes. This demonstrates that the chicken can be a convenient model for studying the molecular biology of human keratin-based diseases.
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