ArticleJournal of controlled release : official journal of the Controlled Release Society2014
Pollen grains for oral vaccination.
Article in Journal of controlled release : official journal of the Controlled Release Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 101 citations in OpenAlex.
- Pot-Pollen Volatiles, Bioactivity, Synergism with Antibiotics, and Bibliometrics Overview, Including Direct Injection in Food Flavor.Foods (Basel, Switzerland) · 2024Review
- Article
- Hidden Pitfalls of Using Onion Pollen in Molecular Research.Current issues in molecular biology · 2023Article
- Chrysanthemum sporopollenin: A novel vaccine delivery system for nasal mucosal immunity.Frontiers in immunology · 2023Article
- Sporopollenin-inspired design and synthesis of robust polymeric materials.Communications chemistry · 2022Article
- Mucosal vaccine delivery: A focus on the breakthrough of specific barriers.Acta pharmaceutica Sinica. B · 2022Review
- Different Plant Sporopollenin Exine Capsules and Their Multifunctional Usage.ACS applied bio materials · 2022Article
- Oral drug delivery for immunoengineering.Bioengineering & translational medicine · 2022Review
- Demystifying particle-based oral vaccines.Expert opinion on drug delivery · 2021Review
- Sustained In Vitro and In Vivo Delivery of Metformin from Plant Pollen-Derived Composite Microcapsules.Pharmaceutics · 2021Article
- Plant Pollen Grains: A Move Towards Green Drug and Vaccine Delivery Systems.Nano-micro letters · 2021Article
- Mechanical design of apertures and the infolding of pollen grain.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Species-Specific Biodegradation of Sporopollenin-Based Microcapsules.Scientific reports · 2019Article
- Novel approaches for the design, delivery and administration of vaccine technologies.Clinical and experimental immunology · 2019Review
- Human blood plasma catalyses the degradation of Lycopodium plant sporoderm microcapsules.Scientific reports · 2019Article
- Pollen grains as a novel microcarrier for oral delivery of proteins.International journal of pharmaceutics · 2018Article
- From allergen to oral vaccine carrier: A new face of ragweed pollen.International journal of pharmaceutics · 2018Article
- A chemical treatment method for obtaining clean and intact pollen shells of different species.ACS biomaterials science & engineering · 2018Article
- Chiral ionic liquids supported on natural sporopollenin microcapsules.RSC advances · 2018Article
- Extraction of cage-like sporopollenin exine capsules from dandelion pollen grains.Scientific reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Oral vaccination can offer a painless and convenient method of vaccination. Furthermore, in addition to systemic immunity it has potential to stimulate mucosal immunity through antigen-processing by the gut-associated lymphoid tissues. In this study we propose the concept that pollen grains can be engineered for use as a simple modular system for oral vaccination. We demonstrate feasibility of this concept by using spores of Lycopodium clavatum (clubmoss) (LSs). We show that LSs can be chemically cleaned to remove native proteins to create intact clean hollow LS shells. Empty pollen shells were successfully filled with molecules of different sizes demonstrating their potential to be broadly applicable as a vaccination system. Using ovalbumin (OVA) as a model antigen, LSs formulated with OVA were orally fed to mice. LSs stimulated significantly higher anti-OVA serum IgG and fecal IgA antibodies compared to those induced by use of cholera toxin as a positive-control adjuvant. The antibody response was not affected by pre-neutralization of the stomach acid, and persisted for up to 7 months. Confocal microscopy revealed that LSs can translocate into mouse intestinal wall. Overall, this study lays the foundation of using LSs as a novel approach for oral vaccination.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.