Evidence map›Paper›PMID 25151968›Full record

ArticleOncogene2015

hTERT mediates norepinephrine-induced Slug expression and ovarian cancer aggressiveness.

M J Choi, K H Cho, S Lee, Y J Bae, K J Jeong, S Y Rha, E J Choi, J H Park, J M Kim, J-S Lee and 2 more

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 79 citations in OpenAlex.

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  17. Fully integrating pathophysiological insights in COPD: an updated working disease model to broaden therapeutic vision.European respiratory review : an official journal of the European Respiratory Society · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

M J ChoiDepartment of Pharmacology, Myunggok Medical Research Institute, College of Medicine, Konyang University, Daejeon, Korea.
K H ChoDepartment of Pharmacology, Myunggok Medical Research Institute, College of Medicine, Konyang University, Daejeon, Korea.
S LeeDepartment of Biochemistry, Myunggok Medical Research Institute, College of Medicine, Konyang University, Daejeon, Korea.
Y J BaeDepartment of Pharmacology, Myunggok Medical Research Institute, College of Medicine, Konyang University, Daejeon, Korea.
K J JeongDepartment of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
S Y RhaYonsei Cancer Research Institute, Yonsei University College of Medicine, Seoul, South Korea.
E J ChoiDepartment of Optometry, College of Medical Science, Konyang University, Daejeon, Korea.
J H ParkDepartment of Biochemistry, Myunggok Medical Research Institute, College of Medicine, Konyang University, Daejeon, Korea.
J M KimCancer Research Institute, Regional Cancer Center and Infection Signaling Network Research Center, Chungnam National University School of Medicine, Daejeon, Korea.
J-S LeeDepartment of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
G B MillsDepartment of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
H Y Lee1] Department of Pharmacology, Myunggok Medical Research Institute, College of Medicine, Konyang University, Daejeon, Korea [2] Yonsei Cancer Research Institute, Yonsei University College of Medicine, Seoul, South Korea.
Konyang University · KRThe University of Texas MD Anderson Cancer Center · USChungnam National University · KRYonsei University · KR

Funding

UNIVERSITY OF TEXAS MD ANDERSON SPORE IN OVARIAN CANCERP50CA083639 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BAST, ROBERT C · 1999 to 2015
$33.0M
6 · The paper itself

Abstract

Stress hormones have been implicated in both tumor initiation and progression. Human telomerase reverse transcriptase (hTERT) is overexpressed in cancer cells and associated with malignant tumor progression and poor outcome. We thus sought to determine whether the stress hormone norepinephrine (NE) could induce hTERT expression and subsequently ovarian cancer progression. Unexpectedly, NE induced hTERT transcript and protein expression, and subsequently ovarian cancer cell invasion. Pharmacologic inhibition of β2-adrenergic receptor 2 and protein kinase A, as well as silencing of hypoxia-inducible factor-1α and c-Myc expression, profoundly attenuated NE-induced hTERT expression. Strikingly, stimulation of the cells with NE or ectopic expression of hTERT induced expression of Slug, ovarian cancer cell epithelial-mesenchymal transition (EMT) and invasion. Silencing of hTERT expression abrogated NE-induced ovarian cancer cell invasion, EMT and Slug expression. In addition, silencing of Slug expression significantly inhibited NE- and hTERT-induced ovarian cancer cell EMT and invasion. Moreover, continuous exposure to NE was sufficient to enhance in vivo hTERT expression and metastasis of ovarian cancer cells to the lung. Finally, we provide evidence that hTERT links Src to Slug expression in NE-induced ovarian cancer EMT and metastasis. We thus demonstrate a novel role of hTERT in stress hormone-induced ovarian cancer aggressiveness through inducing Slug, providing novel biomarkers and potential therapeutic targets for ovarian cancer.

Indexed as

AnimalsFemaleGene Expression Regulation, NeoplasticHumansMiceMice, NudeNeoplasm InvasivenessNeoplasm MetastasisNorepinephrineOvarian NeoplasmsSnail Family Transcription FactorsTelomeraseTranscription FactorsTumor Cells, CulturedUp-RegulationNorepinephrineSNAI1 protein, humanSnai2 protein, mouseSnail Family Transcription FactorsTelomeraseTERT protein, humanTranscription Factors

Identifiers

PMID25151968
OpenAlexW2065247176

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.