Evidence map›Paper›PMID 25151493›Full record

ArticleDrug safety2014

Text mining for adverse drug events: the promise, challenges, and state of the art.

Rave Harpaz, Alison Callahan, Suzanne Tamang, Yen Low, David Odgers, Sam Finlayson, Kenneth Jung, Paea LePendu, Nigam H Shah

Abstract read
In one paragraph

Article in Drug safety, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Medication-indication knowledge bases: a systematic review and critical appraisal.Journal of the American Medical Informatics Association : JAMIA · 2015
    Pooled it
  4. Trial
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Probing Large Language Model Hidden States for Adverse Drug Reaction Knowledge.medRxiv : the preprint server for health sciences · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Observational
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rave HarpazCenter for Biomedical Informatics Research, Stanford University, 1265 Welch Road, Stanford, CA, 94305-5479, USA, rharpaz@stanford.edu.
Alison Callahan
Suzanne Tamang
Yen Low
David Odgers
Sam Finlayson
Kenneth Jung
Paea LePendu
Nigam H Shah

Funding

STANFORD COMPOSITE(RMI)U54HG004028 · NHGRI · STANFORD UNIVERSITY · PI MUSEN, MARK A · 2005 to 2014
$36.2M
POSTDOCTORAL TRAINING IN MEDICAL INFORMATION SCIENCEST15LM007033 · NLM · STANFORD UNIVERSITY · PI SYLVIA KATINA PLEVRITIS · 1985 to 2026
$25.5M
Mining health data for drug safety profilesR01GM101430 · NIGMS · STANFORD UNIVERSITY · PI SHAH, NIGAM H · 2013 to 2017
$2.9M
NHGRI NIH HHS U54 HG004028NHGRI NIH HHS U54-HG004028NIGMS NIH HHS GM101430-01A1NIGMS NIH HHS R01 GM101430NLM NIH HHS T15 LM007033
6 · The paper itself

Abstract

Text mining is the computational process of extracting meaningful information from large amounts of unstructured text. It is emerging as a tool to leverage underutilized data sources that can improve pharmacovigilance, including the objective of adverse drug event (ADE) detection and assessment. This article provides an overview of recent advances in pharmacovigilance driven by the application of text mining, and discusses several data sources-such as biomedical literature, clinical narratives, product labeling, social media, and Web search logs-that are amenable to text mining for pharmacovigilance. Given the state of the art, it appears text mining can be applied to extract useful ADE-related information from multiple textual sources. Nonetheless, further research is required to address remaining technical challenges associated with the text mining methodologies, and to conclusively determine the relative contribution of each textual source to improving pharmacovigilance.

Indexed as

Data CollectionPharmacovigilanceDatabases, FactualData MiningDrug LabelingHumansInternetPeriodicals as TopicSocial Media

Identifiers

PMID25151493
PMCPMC4217510

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.