Evidence map›Paper›PMID 25151338›Full record

ArticleJournal of psychiatric research2014

Abnormal deactivation of the inferior frontal gyrus during implicit emotion processing in youth with bipolar disorder: attenuated by medication.

Danella M Hafeman, Genna Bebko, Michele A Bertocci, Jay C Fournier, Lisa Bonar, Susan B Perlman, Michael Travis, Mary Kay Gill, Vaibhav A Diwadkar, Jeffrey L Sunshine and 12 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatric research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 43 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Neural function during emotion regulation and future depressive symptoms in youth at risk for affective disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Neural Markers in Pediatric Bipolar Disorder and Familial Risk for Bipolar Disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 11 institutions in 2 countries.

Danella M HafemanPsychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, USA. Electronic address: hafemand@upmc.edu.
Genna BebkoPsychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, USA.
Michele A BertocciPsychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, USA.
Jay C FournierPsychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, USA.
Lisa BonarPsychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, USA.
Susan B PerlmanPsychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, USA.
Michael TravisPsychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, USA.
Mary Kay GillPsychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, USA.
Vaibhav A DiwadkarPsychiatry and Behavioral Neuroscience, Wayne State University, USA.
Jeffrey L SunshineUniversity Hospitals Case Medical Center/Case Western Reserve University, USA.
Scott K HollandCincinnati Children's Hospital Medical Center, University of Cincinnati, USA.
Robert A KowatchThe Research Institute at Nationwide Children's Hospital, USA.
Boris BirmaherPsychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, USA.
David AxelsonPsychiatry, Ohio State University, USA.
Sarah M HorwitzChild Psychiatry, New York University School of Medicine, USA.
L Eugene ArnoldPsychiatry, Ohio State University, USA.
Mary A FristadPsychiatry, Ohio State University, USA.
Thomas W FrazierCleveland Clinic, Center for Pediatric Behavioral Health, USA.
Eric A YoungstromPsychology, University of North Carolina at Chapel Hill, USA.
Robert L FindlingUniversity Hospitals Case Medical Center/Case Western Reserve University, USA; Psychiatry, Johns Hopkins University, USA.
Wayne DrevetsJanssen Pharmaceuticals Research & Development of Johnson & Johnson, USA.
Mary L PhillipsPsychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, USA; Psychological Medicine, Cardiff University, UK.
University of Pittsburgh · USCardiff University · GBCase Western Reserve University · USCincinnati Children's Hospital Medical Center · USCleveland Clinic · USJohns Hopkins University · USJohnson & Johnson (United States) · USNationwide Children's Hospital · USNew York University · USUniversity of North Carolina at Chapel Hill · USWayne State University · US

Funding

Longitudinal Assessment of Manic SymptomsR01MH073967 · NIMH · JOHNS HOPKINS UNIVERSITY · PI FINDLING, ROBERT L · 2005 to 2016
$11.4M
CLINICAL RESEARCH TRAINING IN CHILD PSYCHIATRYT32MH018951 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TINA R GOLDSTEIN · 1990 to 2026
$9.7M
Longitudinal Assessment of Manic Symptoms (LAMS)R01MH073953 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BIRMAHER, BORIS, PHILLIPS, MARY LOUISE · 2005 to 2016
$8.7M
Research Methods CoreP30MH090322 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MCKAY, MARY MCKERNAN · 2011 to 2015
$8.1M
Longitudinal Assessment of Manic Symptoms (LAMS)R01MH073816 · NIMH · CINCINNATI CHILDRENS HOSP MED CTR · PI HOLLAND, SCOTT K. · 2005 to 2016
$5.9M
Longitudinal Assessment of Manic Symptoms (LAMS) StudyR01MH073801 · NIMH · OHIO STATE UNIVERSITY · PI FRISTAD, MARY A · 2005 to 2016
$5.9M
Neural Markers of Individual Difference in Emotion Regulation in Depressed AdultsK23MH097889 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FOURNIER, JAY C · 2013 to 2017
$786k
NIMH NIH HHS 3R01MH073953-08S1NIMH NIH HHS 5R01MH073953-08NIMH NIH HHS K23 MH097889NIMH NIH HHS P30 MH090322NIMH NIH HHS R01 MH073801NIMH NIH HHS R01 MH073816NIMH NIH HHS R01 MH073953NIMH NIH HHS R01 MH073967
6 · The paper itself

Abstract

Previous neuroimaging studies of youth with bipolar disorder (BD) have identified abnormalities in emotion regulation circuitry. Using data from the Longitudinal Assessment of Manic Symptoms Cohort (a clinical sample recruited for behavioral and emotional dysregulation), we examined the impact of BD and medication on activation in these regions. Functional neuroimaging data were obtained from 15 youth with BD who currently were unmedicated with a mood stabilizer or antipsychotic (U-BD), 19 youth with medicated BD (M-BD), a non-bipolar clinical sample with high rates of disruptive behavioral disorders (non-BD, n = 59), and 29 healthy controls (HC) while they were shown task-irrelevant morphing emotional faces and shapes. Whole brain analysis was used to identify clusters that showed differential activation to emotion vs. shapes across group. To assess pair-wise comparisons and potential confounders, mean activation data were extracted only from clusters within regions previously implicated in emotion regulation (including amygdala and ventral prefrontal regions). A cluster in the right inferior frontal gyrus (IFG) showed group differences to emotion vs. shapes (159 voxels, corrected p < .05). Within this cluster, U-BD youth showed decreased activation relative to HC (p = .007) and non-BD (p = .004) youth. M-BD also showed decreased activation in this cluster relative to HC and non-BD youth, but these differences were attenuated. Results were specific to negative emotions, and not found with happy faces. IFG findings were not explained by other medications (e.g. stimulants) or diagnoses. Compared to both HC and a non-BD sample, U-BD is associated with abnormally decreased right IFG activation to negative emotions.

Indexed as

AdolescentAmygdalaAntipsychotic AgentsBipolar DisorderBrain MappingCase-Control StudiesChildEmotionsFaceFacial ExpressionFemaleFrontal LobeFunctional LateralityHumansImage Processing, Computer-AssistedLinear ModelsAntipsychotic AgentsOxygenBipolar disorderEmotion regulationFunctional MRI (fMRI)NeuroimagingPsychopharmacology

Identifiers

PMID25151338
PMCPMC4381734
OpenAlexW2051276034

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.