Evidence map›Paper›PMID 25150939›Full record

ArticleAtherosclerosis2014

Development of a new diabetes risk prediction tool for incident coronary heart disease events: the Multi-Ethnic Study of Atherosclerosis and the Heinz Nixdorf Recall Study.

Joseph Yeboah, Raimund Erbel, Joseph Chris Delaney, Robin Nance, Mengye Guo, Alain G Bertoni, Matthew Budoff, Susanne Moebus, Karl-Heinz Jöckel, Gregory L Burke and 5 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Atherosclerosis, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 3 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 3 syntheses or guidelines pooled it, 69 citations in OpenAlex.

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  18. Vascular Age as a Cardiovascular Risk Marker in Asymptomatic Patients with Type 2 Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020
    Article
  19. To Whom Thrombus Aspiration May Concern?Open access Macedonian journal of medical sciences · 2019
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 2 countries.

Joseph YeboahDepartment of Internal Medicine/Cardiology, Wake Forest University Health Sciences, Winston-Salem, NC, USA. Electronic address: jyeboah@wakehealth.edu.
Raimund ErbelDepartment of Cardiology, West-German Heart Center Essen, University Duisburg-Essen, Germany.
Joseph Chris DelaneyDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Robin NanceDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Mengye GuoDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Alain G BertoniDivision of Public Health Sciences, Wake Forest University Health Sciences, Winston-Salem, NC, USA.
Matthew BudoffLos Angeles Biomedical Research Center, Torrance, CA, USA.
Susanne MoebusInstitute of Medical Informatics, Biometry, and Epidemiology, University Duisburg-Essen, Germany.
Karl-Heinz JöckelInstitute of Medical Informatics, Biometry, and Epidemiology, University Duisburg-Essen, Germany.
Gregory L BurkeDivision of Public Health Sciences, Wake Forest University Health Sciences, Winston-Salem, NC, USA.
Nathan D WongHeart Disease Prevention Program, Division of Cardiology, University of California, Irvine, CA, USA.
Nils LehmannDepartment of Cardiology, West-German Heart Center Essen, University Duisburg-Essen, Germany.
David M HerringtonDepartment of Internal Medicine/Cardiology, Wake Forest University Health Sciences, Winston-Salem, NC, USA.
Stefan MöhlenkampClinic of Cardiology, Bethanien Hospital Moers, Germany.
Philip GreenlandDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Wake Forest University · USUniversity of Washington · USWest German Heart and Vascular Center Essen · DEZimmer Biomet (Germany) · DEKrankenhaus Bethanien · DENorthwestern University · USThe Lundquist Institute · USUniversity of California, Irvine · US

Funding

Longitudinal Changes in Pericardial Adiposity and Subclinical AtherosclerosisR01HL098445 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CARR, JOHN JEFFREY · 2010 to 2013
$4.6M
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095165 · HC · WAKE FOREST UNIVERSITY · PI BURKE, GREGORY L · 1999 to 2001
$616k
Longitudinal Methods for Cardiovascular Disease ResearchR01HL103729 · NHLBI · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, ROBYN LEAGH · 2011 to 2013
$592k
Enhancing immune reconstitution after implantation of postnatal allogeneic thymusR21HL095165 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CROOKS, GAY M · 2008 to 2009
$440k
SUBCLINICAL CARDIOVASCULAR DISEASE COORDINATING CENTER-N01HC95159-268095159N01HC095159 · HC · UNIVERSITY OF WASHINGTON · PI KRONMAL, RICHARD A · 1999 to 2006
$304k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-ULTRASOUNDN01HC095167 · HC · TUFTS MEDICAL CENTER · PI O'LEARY, DANIEL H. · 1999 to 2001
$62k
NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01-HC-95159NHLBI NIH HHS N01-HC-95167NHLBI NIH HHS R01 HL098445NHLBI NIH HHS R01HL098445NHLBI NIH HHS R01 HL103729NHLBI NIH HHS R01 HL 103729-01A1
6 · The paper itself

Abstract

objectiveWe develop a new diabetes CHD risk estimator using traditional risk factors plus coronary artery calcium (CAC), ankle-brachial index (ABI), high sensitivity C-reactive protein, family history of CHD, and carotid intima-media thickness and compared it with United Kingdom Prospective Diabetes study (UKPDS), Framingham risk and the NCEP/ATP III risk scores in type 2 diabetes mellitus (T2DM). METHODS AND

resultsWe combined data from T2DM without clinical CVD in the Multi-Ethnic Study of Atherosclerosis (MESA) and the Heinz Nixdorf Recall Study (N = 1343). After a mean follow-up of 8.5 years, 85 (6.3%) participants had incident CHD. Among the novel risk markers, CAC best predicted CHD independent of the FRS [hazard ratio: HR (95% CI): log (CAC +25):1.69 (1.45-1.97), p < 0.0001; CAC categories: CAC ≤ 25 as reference, >25 and ≤125:2.29 (0.87-5.95), >125 and ≤400: 3.87 (1.57-9.57), >400: 5.97 (2.57-13.84), respectively). The MESA-HNR diabetes CHD risk score has better accuracy for the main outcome versus the FRS or UKPDS [area under curve (AUC) of 0.76 vs. 0.70 and 0.69, respectively; all p < 0.05]. The MESA-HNR risk score improved risk classification versus the FRS (net reclassification improvement (NRI) = 0.19 and integrated discrimination improvement (IDI) = 0.046, p < 0.05) and UKPDS (NRI = 0.215 and IDI = 0.046, p < 0.05). Compared with the ATP III guidelines, the MESA-HNR score has an NRI of 0.74 for the main outcome.

conclusionsThis new CHD risk estimator has better discriminative ability for incident CHD than the FRS, UKPDS, and the ATP III/NCEP recommendations in a multi-ethnic cohort with T2DM.

Indexed as

AgedAged, 80 and overAnkle Brachial IndexArea Under CurveCalciumCarotid Intima-Media ThicknessCohort StudiesComorbidityCoronary Artery DiseaseCoronary DiseaseC-Reactive ProteinDiabetes ComplicationsDiabetes Mellitus, Type 2EthnicityFemaleGermanyCalciumC-Reactive ProteinCoronary calcium scoreCoronary heart diseaseDiabetes mellitusRisk assessment

Identifiers

PMID25150939
PMCPMC4170005
OpenAlexW2159984894

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.