Evidence map›Paper›PMID 25150565›Full record

ReviewThe Psychiatric clinics of North America2014

Genetics of obsessive-compulsive disorder and related disorders.

Heidi A Browne, Shannon L Gair, Jeremiah M Scharf, Dorothy E Grice

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Psychiatric clinics of North America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 4 pooled it
6.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 4 syntheses or guidelines pooled it, 93 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Genetics of OCD and Related Disorders; Searching for Shared Factors.Current topics in behavioral neurosciences · 2021
    Pooled it
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Skin picking disorder: Does a person's sex matter?Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists · 2022
    Article
  14. Review
  15. Review
  16. Genetics of obsessive-compulsive disorder.Psychological medicine · 2021
    Review
  17. Article
  18. Review
  19. Article
  20. Astroglia and Obsessive Compulsive Disorder.Advances in neurobiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Heidi A BrowneOCD and Related Disorders Program, Division of Tics, OCD, and Related Disorders, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1230, New York, NY 10029, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.
Shannon L GairOCD and Related Disorders Program, Division of Tics, OCD, and Related Disorders, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1230, New York, NY 10029, USA.
Jeremiah M ScharfMovement Disorders Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, 6254, Boston, MA 02114, USA; Psychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, 6254, Boston, MA 02114, USA. Electronic address: jscharf@partners.org.
Dorothy E GriceOCD and Related Disorders Program, Division of Tics, OCD, and Related Disorders, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1230, New York, NY 10029, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA. Electronic address: dorothy.grice@mssm.edu.
Icahn School of Medicine at Mount Sinai · USAllen Institute for Brain Science · USHarvard University · US

Funding

A Genetic Linkage Study of GTSU01NS040024 · NINDS · TOURETTE ASSOCIATION OF AMERICA, INC. · PI SCHARF, JEREMIAH M · 2007 to 2012
$8.0M
Advancing Tourette Syndrome genetics using bioinformatics and genome biologyK02NS085048 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI SCHARF, JEREMIAH M · 2014 to 2018
$1.0M
6/8-Collaborative genomic studies of Tourette DisorderR01MH092516 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI GRICE, DOROTHY E · 2011 to 2013
$240k
NIMH NIH HHS R01 MH092516NINDS NIH HHS K02 NS085048NINDS NIH HHS U01 NS40024
6 · The paper itself

Abstract

Twin and family studies support a significant genetic contribution to obsessive-compulsive disorder (OCD) and related disorders, such as chronic tic disorders, trichotillomania, skin-picking disorder, body dysmorphic disorder, and hoarding disorder. Recently, population-based studies and novel laboratory-based methods have confirmed substantial heritability in OCD. Genome-wide association studies and candidate gene association studies have provided information on specific gene variations that may be involved in the pathobiology of OCD, though a substantial portion of the genetic risk architecture remains unknown.

Indexed as

AnimalsBody Dysmorphic DisordersChronic DiseaseDisease Models, AnimalDiseases in TwinsFamily HealthGenetic Association StudiesHumansObsessive-Compulsive DisorderRecurrenceTic DisordersTourette SyndromeTrichotillomaniaCandidate geneFamilial recurrenceGeneticsGWASHeritabilityModel systemOCDTwin study

Identifiers

PMID25150565
PMCPMC4143777
OpenAlexW1987911043

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.