ArticleBMC infectious diseases2014
Hepatitis A and E seroprevalence and associated risk factors: a community-based cross-sectional survey in rural Amazonia.
Article in BMC infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Seroprevalence of hepatitis E virus infection in the Americas: Estimates from a systematic review and meta-analysis.PloS one · 2022Pooled it
- Seroprevalence of hepatitis E in adults in Brazil: a systematic review and meta-analysis.Infectious diseases of poverty · 2019Pooled it
- Hepatitis E Virus Infection in Brazil: A Scoping Review of Epidemiological Features.Pathogens (Basel, Switzerland) · 2025Article
- Article
- Seroprevalence of the Hepatitis E Virus in Indigenous and Non-Indigenous Communities from the Brazilian Amazon Basin.Microorganisms · 2024Article
- The burden of hepatitis E virus infection among Ghanaian pregnant women.Frontiers in public health · 2024Article
- Seroconversion and seroreversion rates of anti-Strongyloides IgG in rural areas of the Amazon: a population-based panel study.Revista do Instituto de Medicina Tropical de Sao Paulo · 2024Article
- Review
- Article
- Hepatitis E seroprevalence and risk factors in humans and pig in Ghana.BMC infectious diseases · 2022Article
- Systematic Review of Hepatitis E Virus in Brazil: A One-Health Approach of the Human-Animal-Environment Triad.Animals : an open access journal from MDPI · 2021Review
- Hepatitis E Virus in People Who Use Crack-Cocaine: A Cross-Sectional Study in a Remote Region of Northern Brazil.Viruses · 2021Article
- Article
- Risk factors for viral hepatitis A infection in Gampaha District, Sri Lanka: an unmatched case control study.BMC public health · 2020Article
- Modeling the hepatitis A epidemiological transition in Brazil and Mexico.Human vaccines & immunotherapeutics · 2017Article
- Risk factors, person, place and time characteristics associated with Hepatitis E Virus outbreak in Napak District, Uganda.BMC infectious diseases · 2017Article
- Changes in cellular proliferation and plasma products are associated with liver failure.World journal of hepatology · 2016Article
- Hepatitis E virus infection in patients with acute non-A, non-B, non-C hepatitis in Central Brazil.Memorias do Instituto Oswaldo Cruz · 2016Article
- Use of Pathogen-Specific Antibody Biomarkers to Estimate Waterborne Infections in Population-Based Settings.Current environmental health reports · 2016Review
- Hepatitis E virus: An ancient hidden enemy in Latin America.World journal of gastroenterology · 2016Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHepatitis A virus (HAV) and hepatitis E virus (HEV) are both transmitted by the faecal-oral route, and represent common causes of acute hepatitis in developing countries. The endemicity of HAV infection has shifted from high to moderate in Brazil. Human cases of HEV infection seem to be rare, although the virus has been detected in swine livestock and effluents of slaughterhouses. This study was to determine the epidemiology of hepatitis A and E in one of the largest agricultural settlements in the Amazon Basin of Brazil.
methodsSerum samples collected from 397 individuals aged between 5 and 90 years during a population-based cross-sectional survey were tested for anti-HAV and anti-HEV antibodies. Associated risk factors and spatial clustering of HAV and HEV seropositivity were also analyzed.
resultsThe overall rate of HAV seropositivity was 82.9% (95% confidence interval (CI), 79.2-86.6%). Multilevel logistic regression analysis identified increasing age (in years; odds ratio (OR), 1.097; 95% CI, 1.050-1.147; P < 0.001) and crowding (OR, 1.603; 95% CI, 1.054-2.440; P = 0.028) as significant risk factors for HAV seropositivity. Anti-HEV IgG was detected in 50/388 settlers (12.9%, 95% CI, 9.5-16.2%). Anti-HEV IgM was detected in 7/43 (16.3%) anti-IgG positive samples, and 4 of them had a confirmed result by immunoblot. Increasing age was the only significant determinant of HEV seropositivity (OR, 1.033; 95% CI, 1.016-1.050; P < 0.001). No significant spatial clustering of HAV and HEV seropositivity was detected in the area.
conclusionsBoth HAV and HEV are endemic, with differing rates of infection in children and adults in this rural setting of the Brazilian Amazon. Anti-HEV prevalence was considerably higher than those previously reported in Brazil. The detection of HEV- specific IgM antibodies in four asymptomatic individuals is highly suggestive of the circulation of HEV in this rural population.
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