Evidence map›Paper›PMID 25149602›Full record

ArticlePlant physiology2014

The VASCULATURE COMPLEXITY AND CONNECTIVITY gene encodes a plant-specific protein required for embryo provasculature development.

Hannetz Roschzttardtz, Julio Paez-Valencia, Tejaswi Dittakavi, Sathya Jali, Francisca C Reyes, Gary Baisa, Pauline Anne, Lionel Gissot, Jean-Christophe Palauqui, Patrick H Masson and 2 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Plant physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Hannetz RoschzttardtzDepartment of Botany (H.R., J.P.-V., T.D., F.C.R., M.S.O.), Department of Genetics (S.J., P.H.M., M.S.O.), and Department of Biochemistry (G.B., S.Y.B.), University of Wisconsin, Madison, Wisconsin 53706;Great Lakes Bioenergy Research Center, Madison, Wisconsin 53706 (H.R., S.J., G.B.); andInstitut National de la Recherche Agronomique and AgroParisTech, Institut Jean-Pierre Bourgin, Unité Mixte de Recherche 1318, Saclay Plant Science, 78000 Versailles, France (P.A., L.G., J.-C.P.) hannetz@gmail.com otegui@wisc.edu.
Julio Paez-ValenciaDepartment of Botany (H.R., J.P.-V., T.D., F.C.R., M.S.O.), Department of Genetics (S.J., P.H.M., M.S.O.), and Department of Biochemistry (G.B., S.Y.B.), University of Wisconsin, Madison, Wisconsin 53706;Great Lakes Bioenergy Research Center, Madison, Wisconsin 53706 (H.R., S.J., G.B.); andInstitut National de la Recherche Agronomique and AgroParisTech, Institut Jean-Pierre Bourgin, Unité Mixte de Recherche 1318, Saclay Plant Science, 78000 Versailles, France (P.A., L.G., J.-C.P.).
Tejaswi DittakaviDepartment of Botany (H.R., J.P.-V., T.D., F.C.R., M.S.O.), Department of Genetics (S.J., P.H.M., M.S.O.), and Department of Biochemistry (G.B., S.Y.B.), University of Wisconsin, Madison, Wisconsin 53706;Great Lakes Bioenergy Research Center, Madison, Wisconsin 53706 (H.R., S.J., G.B.); andInstitut National de la Recherche Agronomique and AgroParisTech, Institut Jean-Pierre Bourgin, Unité Mixte de Recherche 1318, Saclay Plant Science, 78000 Versailles, France (P.A., L.G., J.-C.P.).
Sathya JaliDepartment of Botany (H.R., J.P.-V., T.D., F.C.R., M.S.O.), Department of Genetics (S.J., P.H.M., M.S.O.), and Department of Biochemistry (G.B., S.Y.B.), University of Wisconsin, Madison, Wisconsin 53706;Great Lakes Bioenergy Research Center, Madison, Wisconsin 53706 (H.R., S.J., G.B.); andInstitut National de la Recherche Agronomique and AgroParisTech, Institut Jean-Pierre Bourgin, Unité Mixte de Recherche 1318, Saclay Plant Science, 78000 Versailles, France (P.A., L.G., J.-C.P.).
Francisca C ReyesDepartment of Botany (H.R., J.P.-V., T.D., F.C.R., M.S.O.), Department of Genetics (S.J., P.H.M., M.S.O.), and Department of Biochemistry (G.B., S.Y.B.), University of Wisconsin, Madison, Wisconsin 53706;Great Lakes Bioenergy Research Center, Madison, Wisconsin 53706 (H.R., S.J., G.B.); andInstitut National de la Recherche Agronomique and AgroParisTech, Institut Jean-Pierre Bourgin, Unité Mixte de Recherche 1318, Saclay Plant Science, 78000 Versailles, France (P.A., L.G., J.-C.P.).
Gary BaisaDepartment of Botany (H.R., J.P.-V., T.D., F.C.R., M.S.O.), Department of Genetics (S.J., P.H.M., M.S.O.), and Department of Biochemistry (G.B., S.Y.B.), University of Wisconsin, Madison, Wisconsin 53706;Great Lakes Bioenergy Research Center, Madison, Wisconsin 53706 (H.R., S.J., G.B.); andInstitut National de la Recherche Agronomique and AgroParisTech, Institut Jean-Pierre Bourgin, Unité Mixte de Recherche 1318, Saclay Plant Science, 78000 Versailles, France (P.A., L.G., J.-C.P.).
Pauline AnneDepartment of Botany (H.R., J.P.-V., T.D., F.C.R., M.S.O.), Department of Genetics (S.J., P.H.M., M.S.O.), and Department of Biochemistry (G.B., S.Y.B.), University of Wisconsin, Madison, Wisconsin 53706;Great Lakes Bioenergy Research Center, Madison, Wisconsin 53706 (H.R., S.J., G.B.); andInstitut National de la Recherche Agronomique and AgroParisTech, Institut Jean-Pierre Bourgin, Unité Mixte de Recherche 1318, Saclay Plant Science, 78000 Versailles, France (P.A., L.G., J.-C.P.).
Lionel GissotDepartment of Botany (H.R., J.P.-V., T.D., F.C.R., M.S.O.), Department of Genetics (S.J., P.H.M., M.S.O.), and Department of Biochemistry (G.B., S.Y.B.), University of Wisconsin, Madison, Wisconsin 53706;Great Lakes Bioenergy Research Center, Madison, Wisconsin 53706 (H.R., S.J., G.B.); andInstitut National de la Recherche Agronomique and AgroParisTech, Institut Jean-Pierre Bourgin, Unité Mixte de Recherche 1318, Saclay Plant Science, 78000 Versailles, France (P.A., L.G., J.-C.P.).
Jean-Christophe PalauquiDepartment of Botany (H.R., J.P.-V., T.D., F.C.R., M.S.O.), Department of Genetics (S.J., P.H.M., M.S.O.), and Department of Biochemistry (G.B., S.Y.B.), University of Wisconsin, Madison, Wisconsin 53706;Great Lakes Bioenergy Research Center, Madison, Wisconsin 53706 (H.R., S.J., G.B.); andInstitut National de la Recherche Agronomique and AgroParisTech, Institut Jean-Pierre Bourgin, Unité Mixte de Recherche 1318, Saclay Plant Science, 78000 Versailles, France (P.A., L.G., J.-C.P.).
Patrick H MassonDepartment of Botany (H.R., J.P.-V., T.D., F.C.R., M.S.O.), Department of Genetics (S.J., P.H.M., M.S.O.), and Department of Biochemistry (G.B., S.Y.B.), University of Wisconsin, Madison, Wisconsin 53706;Great Lakes Bioenergy Research Center, Madison, Wisconsin 53706 (H.R., S.J., G.B.); andInstitut National de la Recherche Agronomique and AgroParisTech, Institut Jean-Pierre Bourgin, Unité Mixte de Recherche 1318, Saclay Plant Science, 78000 Versailles, France (P.A., L.G., J.-C.P.).
Sebastian Y BednarekDepartment of Botany (H.R., J.P.-V., T.D., F.C.R., M.S.O.), Department of Genetics (S.J., P.H.M., M.S.O.), and Department of Biochemistry (G.B., S.Y.B.), University of Wisconsin, Madison, Wisconsin 53706;Great Lakes Bioenergy Research Center, Madison, Wisconsin 53706 (H.R., S.J., G.B.); andInstitut National de la Recherche Agronomique and AgroParisTech, Institut Jean-Pierre Bourgin, Unité Mixte de Recherche 1318, Saclay Plant Science, 78000 Versailles, France (P.A., L.G., J.-C.P.).ORCID http://orcid.org/0000-0001-7465-1787
Marisa S OteguiDepartment of Botany (H.R., J.P.-V., T.D., F.C.R., M.S.O.), Department of Genetics (S.J., P.H.M., M.S.O.), and Department of Biochemistry (G.B., S.Y.B.), University of Wisconsin, Madison, Wisconsin 53706;Great Lakes Bioenergy Research Center, Madison, Wisconsin 53706 (H.R., S.J., G.B.); andInstitut National de la Recherche Agronomique and AgroParisTech, Institut Jean-Pierre Bourgin, Unité Mixte de Recherche 1318, Saclay Plant Science, 78000 Versailles, France (P.A., L.G., J.-C.P.) hannetz@gmail.com otegui@wisc.edu.ORCID http://orcid.org/0000-0003-4699-6950
University of Wisconsin–Madison · USAgroParisTech · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The molecular mechanisms by which vascular tissues acquire their identities are largely unknown. Here, we report on the identification and characterization of VASCULATURE COMPLEXITY AND CONNECTIVITY (VCC), a member of a 15-member, plant-specific gene family in Arabidopsis (Arabidopsis thaliana) that encodes proteins of unknown function with four predicted transmembrane domains. Homozygous vcc mutants displayed cotyledon vein networks of reduced complexity and disconnected veins. Similar disconnections or gaps were observed in the provasculature of vcc embryos, indicating that defects in vein connectivity appear early in mutant embryo development. Consistently, the overexpression of VCC leads to an unusually high proportion of cotyledons with high-complexity vein networks. Neither auxin distribution nor the polar localization of the auxin efflux carrier were affected in vcc mutant embryos. Expression of VCC was detected in developing embryos and procambial, cambial, and vascular cells of cotyledons, leaves, roots, hypocotyls, and anthers. To evaluate possible genetic interactions with other genes that control vasculature patterning in embryos, we generated a double mutant for VCC and OCTOPUS (OPS). The vcc ops double mutant embryos showed a complete loss of high-complexity vascular networks in cotyledons and a drastic increase in both provascular and vascular disconnections. In addition, VCC and OPS interact physically, suggesting that VCC and OPS are part of a complex that controls cotyledon vascular complexity.

Indexed as

Genes, PlantAmino Acid SequenceArabidopsisArabidopsis ProteinsMolecular Sequence DataPolymerase Chain ReactionSeedsSequence Homology, Amino AcidArabidopsis Proteins

Identifiers

PMID25149602
PMCPMC4213116
OpenAlexW1989845551

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.