ArticleThe American journal of emergency medicine2014
Factors influencing the development of antibiotic associated diarrhea in ED patients discharged home: risk of administering IV antibiotics.
Article in The American journal of emergency medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Management of acute pyelonephritis: a systematic review of oral versus single-dose intravenous followed by oral antibiotic treatment.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Pooled it
- A worldwide systematic review and meta-analysis of bacteria related to antibiotic-associated diarrhea in hospitalized patients.PloS one · 2021Pooled it
- Appropriate Duration of Antimicrobial Treatment for Prosthetic Joint Infections: A Narrative Review.Antibiotics (Basel, Switzerland) · 2024Review
- Intravenous Antibiotic Susceptibility for Urinary Tract Infection Prior to Emergency Department Discharge.Hospital pharmacy · 2021Article
- Clostridium difficile: Diagnosis and the Consequence of Over Diagnosis.Infectious diseases and therapy · 2021Review
- Clinical characteristics and factors related to antibiotic-associated diarrhea in elderly patients with pneumonia: a retrospective cohort study.BMC geriatrics · 2021Article
- Fecal Recovery of Probiotics Administered as a Multi-Strain Formulation during Antibiotic Treatment.Biomedicines · 2020Article
- Risk and Protective Factors for Gastrointestinal Symptoms associated with Antibiotic Treatment in Children: A Population Study.Pediatric gastroenterology, hepatology & nutrition · 2020Article
- Antibiotic-associated diarrhoea in emergency department observation unit patients.Epidemiology and infection · 2016Article
- Clinical practice guideline: management of acute pancreatitis.Canadian journal of surgery. Journal canadien de chirurgie · 2016Review
- Treatment of bacterial skin infections in ED observation units: factors influencing prescribing practice.The American journal of emergency medicine · 2015Article
- Role of antimicrobials in the treatment of adult patients presenting to the emergency department with acute gastroenteritis - A mini review.Pakistan journal of medical sciencesReview
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveAntibiotic-associated diarrhea (AAD) and Clostridium difficile infection (CDI) are well-known outcomes from antibiotic administration. Because emergency department (ED) visits frequently result in antibiotic use, we evaluated the frequency of AAD/CDI in adults treated and discharged home with new prescriptions for antibiotics to identify risk factors for acquiring AAD/CDI.
methodsThis prospective multicenter cohort study enrolled adult patients who received antibiotics in the ED and were discharged with a new prescription for antibiotics. Antibiotic-associated diarrhea was defined as 3 or more loose stools for 2 days or more within 30 days of starting the antibiotic. C difficile infection was defined by the detection of toxin A or B within this same period. We used multivariate logistic regression to assess predictors of developing AAD.
resultsWe enrolled and followed 247 patients; 45 (18%) developed AAD, and 2 (1%) developed CDI. Patients who received intravenous (IV) antibiotics in the ED were more likely to develop AAD/CDI than patients who did not: 25.7% (95% confidence interval [CI], 17.4-34.0) vs 12.3% (95% CI, 6.8-17.9). Intravenous antibiotics had adjusted odds ratio of 2.73 (95% CI, 1.38-5.43), and Hispanic ethnicity had adjusted odds ratio of 3.04 (95% CI, 1.40-6.58). Both patients with CDI had received IV doses of broad-spectrum antibiotics.
conclusionIntravenous antibiotic therapy administered to ED patients before discharge was associated with higher rates of AAD and with 2 cases of CDI. Care should be taken when deciding to use broad-spectrum IV antibiotics to treat ED patients before discharge home.
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