ArticleThe Plant cell2014
Loss of ceramide kinase in Arabidopsis impairs defenses and promotes ceramide accumulation and mitochondrial H2O2 bursts.
Article in The Plant cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 108 citations in OpenAlex.
- Ceramides play a significant role in the response of Pogostemon cablin to bacterial wilt by regulating the ABA pathway.BMC plant biology · 2025Article
- Identification of INOSITOL PHOSPHORYLCERAMIDE SYNTHASE 2 (IPCS2) as a new rate-limiting component in Arabidopsis pathogen entry control.The Plant journal : for cell and molecular biology · 2025Article
- Sphingosine Promotes Fiber Early Elongation in Upland Cotton.Plants (Basel, Switzerland) · 2024Article
- Ceramide kinase-mediated C1P metabolism attenuates acute liver injury by inhibiting the interaction between KEAP1 and NRF2.Experimental & molecular medicine · 2024Article
- Exploring the plant lipidome: techniques, challenges, and prospects.Advanced biotechnology · 2024Review
- Chloride salt enhances plant resistance to biotic stresses.Frontiers in plant science · 2024Article
- TheHorticulture research · 2024Article
- Substance P promotes epidural fibrosis via induction of type 2 macrophages.Neural regeneration research · 2023Article
- TaRBP1 stabilizes TaGLTP and negatively regulates stripe rust resistance in wheat.Molecular plant pathology · 2023Article
- Defining the lipidome of Arabidopsis leaf mitochondria: Specific lipid complement and biosynthesis capacity.Plant physiology · 2023Article
- Comparative proteomic analysis identifies proteins associated with arbuscular mycorrhizal symbiosis inFrontiers in plant science · 2023Article
- Transcriptome analysis ofFrontiers in microbiology · 2023Article
- Sphingolipids are involved in insect egg-induced cell death in Arabidopsis.Plant physiology · 2022Article
- Plant elicitor peptide signalling confers rice resistance to piercing-sucking insect herbivores and pathogens.Plant biotechnology journal · 2022Article
- Study of Chemical Compositions and Anticancer Effects ofMolecules (Basel, Switzerland) · 2022Article
- Sphingolipid-Induced Programmed Cell Death is a Salicylic Acid and EDS1-Dependent Phenotype in Arabidopsis Fatty Acid Hydroxylase (Fah1, Fah2) and Ceramide Synthase (Loh2) Triple Mutants.Plant & cell physiology · 2022Article
- The Two Classes of Ceramide Synthases Play Different Roles in Plant Immunity and Cell Death.Frontiers in plant science · 2022Article
- Grape Lipidomics: An Extensive Profiling thorough UHPLC-MS/MS Method.Metabolites · 2021Article
- Jasmonates modulate sphingolipid metabolism and accelerate cell death in the ceramide kinase mutant acd5.Plant physiology · 2021Article
- Metabolomics Response to Drought Stress inPlants (Basel, Switzerland) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 2 institutions in 2 countries.
Funding
Abstract
Arabidopsis thaliana plants that lack ceramide kinase, encoded by ACCELERATED CELL DEATH5 (ACD5), display spontaneous programmed cell death late in development and accumulate substrates of ACD5. Here, we compared ceramide accumulation kinetics, defense responses, ultrastructural features, and sites of reactive oxygen species (ROS) production in wild-type and acd5 plants during development and/or Botrytis cinerea infection. Quantitative sphingolipid profiling indicated that ceramide accumulation in acd5 paralleled the appearance of spontaneous cell death, and it was accompanied by autophagy and mitochondrial ROS accumulation. Plants lacking ACD5 differed significantly from the wild type in their responses to B. cinerea, showing earlier and higher increases in ceramides, greater disease, smaller cell wall appositions (papillae), reduced callose deposition and apoplastic ROS, and increased mitochondrial ROS. Together, these data show that ceramide kinase greatly affects sphingolipid metabolism and the site of ROS accumulation during development and infection, which likely explains the developmental and infection-related cell death phenotypes. The acd5 plants also showed an early defect in restricting B. cinerea germination and growth, which occurred prior to the onset of cell death. This early defect in B. cinerea restriction in acd5 points to a role for ceramide phosphate and/or the balance of ceramides in mediating early antifungal responses that are independent of cell death.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.