ArticleSleep & breathing = Schlaf & Atmung2015
The effect of vitamin D supplements on the severity of restless legs syndrome.
Article in Sleep & breathing = Schlaf & Atmung, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Treatment of restless legs syndrome and periodic limb movement disorder: an American Academy of Sleep Medicine systematic review, meta-analysis, and GRADE assessment.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Pooled it
- Vitamin D and Hyperkinetic Movement Disorders: A Systematic Review.Tremor and other hyperkinetic movements (New York, N.Y.) · 2020Pooled it
- Effect of dairy products fortified with vitamin dBMC women's health · 2024Trial
- Efficacy of vitamin D replacement therapy in restless legs syndrome: a randomized control trial.Sleep & breathing = Schlaf & Atmung · 2019Trial
- Restless legs syndrome in children with celiac disease: associations with vitamin D and iron deficiency and the role of gluten-free diet adherence.BMC pediatrics · 2026Article
- Vitamin D and Sleep Disorders.Advances in experimental medicine and biology · 2026Review
- Pediatric sleep movements: a review of methodologies, normative data, disease associations, and research gaps.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Review
- The association between vitamin D and restless legs syndrome following acute ischemic stroke.Scientific reports · 2025Article
- Vitamin D replacement therapy may regulate sleep habits in patients with restless leg syndrome.Open medicine (Warsaw, Poland) · 2025Article
- Amelioration of obsessive-compulsive disorder by intracellular acidification of cortical neurons with a proton pump inhibitor.Translational psychiatry · 2024Article
- Determination of optimal 25-hydroxyvitamin D cutoff values for the evaluation of restless legs syndrome among pregnant women.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023Article
- Exploring the causes of augmentation in restless legs syndrome.Frontiers in neurology · 2023Review
- Vitamin D and Restless Legs Syndrome: A Review of Current Literature.Tremor and other hyperkinetic movements (New York, N.Y.) · 2023Review
- Behavioral sleep medicine-The need for harmonization of clinical best practice outcome measures in children and adolescents with intellectual or developmental disabilities and restless sleep.Frontiers in psychiatry · 2022Review
- Article
- Analysis of Serum Vitamin D Level and Related Factors in Patients With Restless Legs Syndrome.Frontiers in neurology · 2021Article
- The effect of vitamin D on restless legs syndrome: prospective self-controlled case study.Sleep & breathing = Schlaf & Atmung · 2020Article
- Prevalence and predictors of restless legs syndrome in non-pregnant Saudi women of childbearing age.Sleep & breathing = Schlaf & Atmung · 2020Article
- The prevalence of insomnia and restless legs syndrome among Japanese outpatients with rheumatic disease: A cross-sectional study.PloS one · 2020Article
- Mineral absorption is an enriched pathway in a brain region of restless legs syndrome patients with reduced MEIS1 expression.PloS one · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeClinical observation hinted improved symptoms of restless legs syndrome (RLS) after vitamin D supplements. Hence, the aim of this study is to evaluate the effect of vitamin D supplementation on the severity of RLS symptoms.
methodsTwelve adult subjects diagnosed with primary RLS and vitamin D deficiency were recruited. Patients with secondary RLS were excluded from this study. The complete cell count; serum levels of ferritin, iron, glycated hemoglobin, and vitamin D3 (25 (OH) vitamin D); and renal and bone profiles of the patients were assayed. Patients with vitamin D deficiency (<50 nmol/l) were treated with vitamin D3 supplements (high oral dose or intramuscular injection). The severity scores of RLS were reassessed after the vitamin D3 level was corrected to >50 nmol/l and compared with those before the administration of the supplements.
resultsThe median pretreatment vitamin D level was 21.7 nmol/l (13.45-57.4), which improved to 61.8 nmol/l (42.58-95.9) (P = 0.002) with the treatment. The median RLS severity score improved significantly from 26 (15-35) at baseline to 10 (0-27) after correction of the vitamin D levels (P = 0.002).
conclusionThis study indicates that vitamin D supplementation improves the severity of RLS symptoms and advocates that vitamin D deficiency is conceivably associated with RLS.
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