SynthesisLangenbeck's archives of surgery2014
The benefits of liver resection for non-colorectal, non-neuroendocrine liver metastases: a systematic review.
Synthesis in Langenbeck's archives of surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Resection of oesophageal and oesophagogastric junction cancer liver metastases - a summary of current evidence.Langenbeck's archives of surgery · 2022Pooled it
- Evaluation of the role of liver metastasectomy in the treatment of stage IV endometrial cancer.Journal of gynecologic oncology · 2025Article
- Surgical results of liver metastases of tumors other than colorectal-neuroendocrine: Is it really worth it or is it necessary?Turkish journal of surgery · 2024Article
- Article
- Approaches to Reducing Normal Tissue Radiation from Radiolabeled Antibodies.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Article
- Addressing hepatic metastases in ovarian cancer: Recent advances in treatment algorithms and the need for a multidisciplinary approach.World journal of hepatology · 2021Review
- Laparoscopic Caudal Approach of the Inferior Vena Cava for Isolated Segment 1 Liver Resection.Journal of gastrointestinal cancer · 2021Article
- Hepatectomy for Breast Cancer Metastasis and Sarcoma are more likely to have Adverse Outcomes than Hepatectomy for Primary Hepatocellular Cancer or for Colorectal Metastasis.Cancer medicine journal · 2020Article
- Perioperative and long-term outcomes of laparoscopic liver resections for non-colorectal liver metastases.Surgical endoscopy · 2020Article
- Liver resection for metastatic thyroid carcinoma. Case report and literature review.Journal of surgical case reports · 2020Article
- Article
- The lack of selection criteria for surgery in patients with non-colorectal non-neuroendocrine liver metastases.World journal of surgical oncology · 2020Article
- Liver Resection as Part of Cytoreductive Surgery for Ovarian Cancer.Journal of gynecologic surgery · 2020Article
- Laparoscopic liver resection for non-colorectal non-neuroendocrine metastases: perioperative and oncologic outcomes.World journal of surgical oncology · 2019Article
- Liver Resection for Hepatic Metastases from Soft Tissue Sarcoma: A Nationwide Study.Digestive surgery · 2019Article
- Pancreatic, periampullary and biliary cancer with liver metastases: Should we consider resection in selected cases?World journal of gastrointestinal oncology · 2018Article
- [Oligometastases in gastric and esophageal cancer : Current clinical trials and surgical concepts].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2018Review
- [Role of visceral surgery in oligometastases of non-gastrointestinal tumors].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2018Review
- Preoperative Prognostic Factors After Liver Resection for Non-Colorectal, Non-Neuroendocrine Liver Metastases and Validation of the Adam Score in an Asian Population.World journal of surgery · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDefining the benefits of resection of isolated non-colorectal, non-neuroendocrine (NCRNNE) liver metastases is difficult. To better understand the survival benefit in this group of patients, we conducted a systematic review of the previous literature.
methodsMedline, Web of Knowledge, and manual searches were performed using search terms, such as "liver resection" and "primary tumor." Inclusion criteria were year>1990, >five patients, and median survival reported or derived. An expected median survival was calculated from weighted averages of median survivals, and differences were assessed using a permutation test.
resultsA total of 7,857 references were identified. Overall 4,735 abstracts were reviewed; 120 manuscripts evaluated and of these, 73 met the study inclusion criteria. The final population consisted of 3,596 patients with renal (n=234), ovarian (n=119), testicular (n=153), adrenal (n=90), small bowel (n=28), gallbladder (n=21), duodenum (n=38), gastric (n=481), pancreatic (n=55), esophageal (n=23), head and neck (n=15), and lung (n=36) cancers, gastrointestinal stromal tumors (GISTs) (n=106), cholangiocarcinoma (n=13), sarcoma (n=189), and melanoma (n=643). The greatest expected median was 63 months for genitourinary (GU) primaries (n=549; range 5.4-142 months) followed by 44.4 months for breast cancer (n=1,013; range 8-74 months), 22.3 months for gastrointestinal cancer (n=549; range 5-58 months), and 23.7 months for other tumor types (n=1,082; range 10-72 months). Using a permutation test, we observed that survival was best for patients with GU primaries followed by that for breast cancer patients. Additionally, we also observed that survival was similar for those with cancer of the GI tract and other primary sites.
conclusionsThere appears to be a benefit to resection for patients with NCRNNE liver metastases. The degree of survival advantage is predicated by primary site.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.