Evidence map›Paper›PMID 25148427›Full record

ReviewAnnals of the American Thoracic Society2014

Infections in the immunosuppressed host.

M Patricia George, Henry Masur, Karen A Norris, Scott M Palmer, Cornelius J Clancy, John F McDyer

Abstract readReview
In one paragraph

Review in Annals of the American Thoracic Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Staphylococcus aureus genotype variation among and within periprosthetic joint infections.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022
    Article
  5. A discussion of syndromic molecular testing for clinical care.The Journal of antimicrobial chemotherapy · 2021
    Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Interplay between Peptidoglycan Biology and Virulence in Gram-Negative Pathogens.Microbiology and molecular biology reviews : MMBR · 2018
    Review
  11. Article
  12. Opportunistic Oral Infections.Dental clinics of North America · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

M Patricia George1 Department of Medicine, and.
Henry Masur
Karen A Norris
Scott M Palmer
Cornelius J Clancy
John F McDyer

Funding

Vascular Subphenotypes of Lung DiseaseP01HL103455 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHIVA, SRUTI · 2011 to 2020
$26.1M
Development of CMV-specific T Cell Memory in Lung Transplant RecipientsR01AI079175 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MCDYER, JOHN F · 2009 to 2012
$1.6M
Genetic Regulation of Lung Transplant OutcomesK24HL091140 · NHLBI · DUKE UNIVERSITY · PI PALMER, SCOTT M · 2008 to 2012
$712k
HAART-mediated Immune Restoration in Chronic Obstructive Pulmonary DiseaseK23HL096467 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GEORGE, MARJORIE PATRICIA · 2011 to 2015
$656k
NHLBI NIH HHS K23 HL096467NHLBI NIH HHS K24 HL091140NHLBI NIH HHS K24-HL091140NHLBI NIH HHS P01 HL103455NIAID NIH HHS R01 AI079175
6 · The paper itself

Abstract

The interaction between host immunity and infections in the context of a suppressed immune system presents an opportunity to study the interaction of colonization and infection with the development of acute and chronic pulmonary morbidity and mortality. This article summarizes presentations at the Pittsburgh International Lung Conference about comorbid consequences in two categories of immunosuppressed hosts: HIV-infected individuals and lung transplant recipients. Specifically, chronic obstructive pulmonary disease, pulmonary hypertension, and chronic lung rejection after transplant are three diseases that may be consequences of colonization or infection by viruses or fungi, whether HIV itself or the opportunistic infections Pneumocystis and cytomegalovirus. In the fourth section, we discuss unique aspects of infections after lung transplant as well as the battle against multidrug-resistant organisms in this population and theorize that the immunosuppressed population may provide a unique group of patients in which to study ways to overcome nosocomial pathogenic challenges. These host-pathogen interactions serve as models for developing new strategies to reduce acute and chronic morbidity due to colonization and subclinical infection, and potential therapeutic avenues, which are often overlooked in the clinical arena.

Indexed as

Adaptive ImmunityHumansImmunocompromised HostRespiratory Tract Infectionscytomegalovirusimmunosuppressed hostlung transplantationPneumocystispulmonary hypertension

Identifiers

PMID25148427
PMCPMC4200572

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.