ArticlePloS one2014
Regional variation in tissue composition and biomechanical properties of postmenopausal ovine and human vagina.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Animal models for pelvic organ prolapse: systematic review.International urogynecology journal · 2021Pooled it
- Assessing Vaginal Wall Elasticity via Shear-Wave Elastography Using a Transrectal Linear Array High-Frequency Probe in Premenopausal versus Postmenopausal Women: A Cross-Sectional Feasibility Study.International journal of women's health · 2026Article
- Decellularization method and tissue region impact the structural properties and composition of porcine vaginal extracellular matrix.Acta biomaterialia · 2026Article
- Bipolar Radiofrequency and Non-Crosslinked Hyaluronic Acid Plus Calcium Hydroxyapatite in the Treatment of Stress Urinary Incontinence.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Current practice in animal models for pelvic floor dysfunction.International urogynecology journal · 2023Review
- Hyaluronic Acid and Radiofrequency in Patients with Urogenital Atrophy and Vaginal Laxity.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Validation of an ovine vesicovaginal fistula model.International urogynecology journal · 2022Article
- A Review of the Diversity of the Genital Tract Microbiome and Implications for Fertility of Cattle.Animals : an open access journal from MDPI · 2022Review
- Endometrial SUSD2Journal of personalized medicine · 2021Review
- Animal Models and Alternatives in Vaginal Research: a Comparative Review.Reproductive sciences (Thousand Oaks, Calif.) · 2021Review
- Tear propagation in vaginal tissue under inflation.Acta biomaterialia · 2021Article
- A novel tropoelastin-based resorbable surgical mesh for pelvic organ prolapse repair.Materials today. Bio · 2020Article
- Experimental study of a new original mesh developed for pelvic floor reconstructive surgery.International urogynecology journal · 2020Article
- Smooth muscle regional contribution to vaginal wall function.Interface focus · 2019Article
- First delivery and ovariectomy affect biomechanical and structural properties of the vagina in the ovine model.International urogynecology journal · 2019Article
- Ovine multiparity is associated with diminished vaginal muscularis, increased elastic fibres and vaginal wall weakness: implication for pelvic organ prolapse.Scientific reports · 2017Article
- Endometrial mesenchymal stem cells as a cell based therapy for pelvic organ prolapse.World journal of stem cells · 2016Review
- Isolation and characterisation of mesenchymal stem/stromal cells in the ovine endometrium.PloS one · 2015Article
- Characterization of the Vaginal Microbiota of Ewes and Cows Reveals a Unique Microbiota with Low Levels of Lactobacilli and Near-Neutral pH.Frontiers in veterinary science · 2014Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThere are increasing numbers of reports describing human vaginal tissue composition in women with and without pelvic organ prolapse with conflicting results. The aim of this study was to compare ovine and human posterior vaginal tissue in terms of histological and biochemical tissue composition and to assess passive biomechanical properties of ovine vagina to further characterise this animal model for pelvic organ prolapse research. STUDY
designVaginal tissue was collected from ovariectomised sheep (n = 6) and from postmenopausal women (n = 7) from the proximal, middle and distal thirds. Tissue histology was analyzed using Masson's Trichrome staining; total collagen was quantified by hydroxyproline assays, collagen III/I+III ratios by delayed reduction SDS PAGE, glycosaminoglycans by dimethylmethylene blue assay, and elastic tissue associated proteins (ETAP) by amino acid analysis. Young's modulus, maximum stress/strain, and permanent strain following cyclic loading were determined in ovine vagina.
resultsBoth sheep and human vaginal tissue showed comparable tissue composition. Ovine vaginal tissue showed significantly higher total collagen and glycosaminoglycan values (p<0.05) nearest the cervix. No significant differences were found along the length of the human vagina for collagen, GAG or ETAP content. The proximal region was the stiffest (Young's modulus, p<0.05), strongest (maximum stress, p<0.05) compared to distal region, and most elastic (permanent strain).
conclusionSheep tissue composition and mechanical properties showed regional differences along the postmenopausal vaginal wall not apparent in human vagina, although the absolute content of proteins were similar. Knowledge of this baseline variation in the composition and mechanical properties of the vaginal wall will assist future studies using sheep as a model for vaginal surgery.
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Registered trials
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