Evidence map›Paper›PMID 25148233›Full record

ArticleThe Journal of clinical endocrinology and metabolism2014

Ratio of urine albumin to creatinine attenuates the association of dementia with hip fracture risk.

Petra Bůžková, Joshua I Barzilay, Howard A Fink, John A Robbins, Jane A Cauley, Annette L Fitzpatrick

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
  2. Association of Increased Urinary Albumin With Risk of Incident Clinical Fracture and Rate of Hip Bone Loss: the Osteoporotic Fractures in Men Study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017
    Trial
  3. Article
  4. Hospitalization Rates in Older Adults With Albuminuria: The Cardiovascular Health Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020
    Article
  5. Article
  6. Review
  7. Systemic markers of microvascular disease and bone mineral density in older adults : The cardiovascular health study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Petra BůžkováDepartment of Biostatistics (P.B.), University of Washington, Seattle, Washington 98115; Division of Endocrinology, Kaiser Permanente of Georgia and the Division of Endocrinology (J.I.B.), Emory University School of Medicine, Atlanta, Georgia 30096; Geriatric Research Education & Clinical Center (H.A.F.), Veterans Affair Medical Center, Minneapolis, Minnesota 55417; Department of Medicine (J.A.R.), University of California, Davis, Sacramento, California; Department of Epidemiology (J.A.C.), Graduate School of Public Health, University of Pittsburgh, Pittsburgh 15261, Pennsylvania; and Department of Epidemiology (A.L.F.), University of Washington, Seattle, Washington 98115.
Joshua I Barzilay
Howard A Fink
John A Robbins
Jane A Cauley
Annette L Fitzpatrick
University of Washington · USEmory University · USGeriatric Research Education and Clinical Center · USUniversity of California, Davis · USUniversity of Pittsburgh · US

Funding

Exceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5M
CHS Events Follow-up StudyR01HL080295 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2009 to 2014
$6.3M
CHS Events Follow-up StudyU01HL080295 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2005 to 2008
$4.6M
Predictors of Alheimers Disease in Mild Cognitive ImpairmentR01AG020098 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LOPEZ, OSCAR L. · 2002 to 2011
$3.7M
Role of EIIIA fibronectin in pulmonary fibrosisR01HL085083 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WHITE, ERIC S · 2007 to 2011
$1.9M
CHS-Transition PhaseN01HC55222 · NHLBI · PI , · 2007 to 2007
$575k
Exceptional Survival: Trajectories to Functional Aging (CHS All Stars)R56AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2010 to 2010
$300k
CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84N01HC085083 · HC · UNIVERSITY OF CALIFORNIA DAVIS · PI ROBBINS, JOHN A · 1988 to 1999
–
MRI READING CENTER FOR THE CARDIOVASCULAR HEALTH STUDYN01HC015103 · HC · JOHNS HOPKINS UNIVERSITY · PI BEAUCHAMP, NORMAN J · 1991 to 1998
–
CENTRAL BLOOD ANALYSIS LABORATORY FOR CHSN01HC085086 · HC · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI TRACY, RUSSELL P · 1988 to 2000
–
CHS-Transition Phase -268055222-268055222N01HC055222 · HC · UNIVERSITY OF WASHINGTON · PI KRONMAL, RICHARD A · 2005 to 2006
–
CHS RETINAL READING CENTERN01HC075150 · HC · UNIVERSITY OF WISCONSIN MADISON · PI KLEIN, RONALD · 1997 to 2000
–
NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HL080295NHLBI NIH HHS N01 HC015103NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC075150NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01HC15103NHLBI NIH HHS N01 HC55222NHLBI NIH HHS R01 HL080295NHLBI NIH HHS U01 HL080295NIA NIH HHS AG023629NIA NIH HHS R01 AG020098NIA NIH HHS R01 AG023629NIA NIH HHS R01AG20098NIA NIH HHS R56 AG023629
6 · The paper itself

Abstract

contextMicrovascular disease is a leading cause of cognitive impairment. Approximately 50% of people with a hip fracture have cognitive impairment.

objectiveWe tested the hypothesis that microvascular diseases of the brain (lacunar infarcts and white matter disease [WMD]), kidney (albuminuria [≥ 30 mg/g creatinine] and albumin creatinine ratio [ACR]), and eye (retinal vascular disorders) attenuate the association of cognitive impairment with hip fracture risk.

settingThe Cardiovascular Health Cognition Study. PATIENTS: Three thousand, one-hundred six participants (mean age, ∼ 79 y; 8.84 y median follow-up) with cognitive testing. Subsets received ACR testing (n=2389), brain magnetic resonance imaging scans (n = 2094), and retinal photography (n = 1098).

main outcome measureIncident hip fracture.

resultsThere were 488 participants (16%) with mild cognitive impairment (MCI) and 564 (18%) with dementia. There were 337 incident hip fractures, of which 19% occurred in participants with MCI and 26% in participants with dementia. Adjusted hazard ratios (HR) and 95% confidence interval for hip fracture in participants with MCI were 2.45 (1.67-3.61) and for dementia 2.35 (1.57-3.52). With doubling of ACR, the HR for fracture was attenuated in participants with dementia compared with participants with normal cognition [interaction HR 0.70 (0.55-0.91)]. No such effect was found in participants with MCI. Albuminuria, lacunar infarcts, WMD, and retinal vascular disease (RVD) did not modify the association of dementia or MCI with hip fracture risk.

conclusionsACR attenuates part of the risk of hip fracture in people with dementia, suggesting that these disorders share a common pathogenesis.

Indexed as

AgedAged, 80 and overAlbuminuriaCognitive DysfunctionCreatinineDementiaFemaleHip FracturesHumansIncidenceMagnetic Resonance ImagingMaleNeuropsychological TestsProspective StudiesRiskCreatinine

Identifiers

PMID25148233
PMCPMC4223436
OpenAlexW2039145159

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.