ArticlePloS one2014
Identification of miRNAs differentially expressed in human epilepsy with or without granule cell pathology.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- MicroRNAs as potential biomarkers in temporal lobe epilepsy and mesial temporal lobe epilepsy.Neural regeneration research · 2023Review
- Infantile status epilepticus disrupts myelin development.Neurobiology of disease · 2022Article
- Identifying genetic risk variants associated with brain volumetric phenotypes via K-sample Ball Divergence method.Genetic epidemiology · 2021Article
- Molecular Chaperones and miRNAs in Epilepsy: Pathogenic Implications and Therapeutic Prospects.International journal of molecular sciences · 2021Review
- Discovery and validation of blood microRNAs as molecular biomarkers of epilepsy: Ways to close current knowledge gaps.Epilepsia open · 2018Review
- From fix to fit into the autoptic human brains.European journal of histochemistry : EJH · 2018Article
- The Challenge of microRNA as a Biomarker of Epilepsy.Current neuropharmacology · 2018Review
- WONOEP appraisal: Development of epilepsy biomarkers-What we can learn from our patients?Epilepsia · 2017Review
- Blood DNA methylation pattern is altered in mesial temporal lobe epilepsy.Scientific reports · 2017Article
- Is autopsy tissue a valid control for epilepsy surgery tissue in microRNA studies?Epilepsia open · 2017Article
- Inhibition of microRNA 128 promotes excitability of cultured cortical neuronal networks.Genome research · 2016Article
- Differential expression of miR-184 in temporal lobe epilepsy patients with and without hippocampal sclerosis - Influence on microglial function.Scientific reports · 2016Article
- Differential gene expression in dentate granule cells in mesial temporal lobe epilepsy with and without hippocampal sclerosis.Epilepsia · 2016Article
- Pilocarpine-induced seizures trigger differential regulation of microRNA-stability related genes in rat hippocampal neurons.Scientific reports · 2016Article
- microRNA targeting of the P2X7 purinoceptor opposes a contralateral epileptogenic focus in the hippocampus.Scientific reports · 2015Article
- MicroRNA profiles in hippocampal granule cells and plasma of rats with pilocarpine-induced epilepsy--comparison with human epileptic samples.Scientific reports · 2015Article
- Hippocampus and epilepsy: Findings from human tissues.Revue neurologique · 2015Review
- Pathway-driven discovery of epilepsy genes.Nature neuroscience · 2015Review
- miRNAs: biological and clinical determinants in epilepsy.Frontiers in molecular neuroscience · 2015Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The microRNAs (miRNAs) are small size non-coding RNAs that regulate expression of target mRNAs at post-transcriptional level. miRNAs differentially expressed under pathological conditions may help identifying mechanisms underlying the disease and may represent biomarkers with prognostic value. However, this kind of studies are difficult in the brain because of the cellular heterogeneity of the tissue and of the limited access to fresh tissue. Here, we focused on a pathology affecting specific cells in a subpopulation of epileptic brains (hippocampal granule cells), an approach that bypasses the above problems. All patients underwent surgery for intractable temporal lobe epilepsy and had hippocampal sclerosis associated with no granule cell pathology in half of the cases and with type-2 granule cell pathology (granule cell layer dispersion or bilamination) in the other half. The expression of more than 1000 miRNAs was examined in the laser-microdissected dentate granule cell layer. Twelve miRNAs were differentially expressed in the two groups. One of these, miR487a, was confirmed to be expressed at highly differential levels in an extended cohort of patients, using RT-qPCR. Bioinformatics searches and RT-qPCR verification identified ANTXR1 as a possible target of miR487a. ANTXR1 may be directly implicated in granule cell dispersion because it is an adhesion molecule that favors cell spreading. Thus, miR487a could be the first identified element of a miRNA signature that may be useful for prognostic evaluation of post-surgical epilepsy and may drive mechanistic studies leading to the identification of therapeutic targets.
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