ArticlePloS one2014
Optogenetic recruitment of dorsal raphe serotonergic neurons acutely decreases mechanosensory responsivity in behaving mice.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Biological correlates of temperament: systematic reviews, empirical studies, and a conceptual framework linking neurotransmitter signaling, intrinsic brain activity, and the hyperthymic-depressive spectrum.Molecular psychiatry · 2025Pooled it
- Serotonergic modulation of the BNST-CeA pathway reveals sex differences in fear learning.Nature neuroscience · 2025Article
- Peri-ictal activation of dorsomedial dorsal raphe serotonin neurons reduces mortality associated with maximal electroshock seizures.Brain communications · 2024Article
- Serotonin neurons in mating female mice are activated by male ejaculation.Current biology : CB · 2023Article
- Differential Serotonergic Modulation of Synaptic Inputs to the Olfactory Cortex.International journal of molecular sciences · 2023Article
- Adolescent ethanol drinking promotes hyperalgesia, neuroinflammation and serotonergic deficits in mice that persist into adulthood.Brain, behavior, and immunity · 2023Article
- Kappa opioids inhibit the GABA/glycine terminals of rostral ventromedial medulla projections in the superficial dorsal horn of the spinal cord.The Journal of physiology · 2022Article
- Differential Serotonergic Modulation of Principal Neurons and Interneurons in the Anterior Piriform Cortex.Frontiers in neuroanatomy · 2022Article
- Article
- State-Dependent Regulation of Cortical Processing Speed via Gain Modulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Hyperactive ACC-MDT Pathway Suppresses Prepulse Inhibition in Mice.Schizophrenia bulletin · 2021Article
- Phasic Activation of Dorsal Raphe Serotonergic Neurons Increases Pupil Size.Current biology : CB · 2021Article
- Two Functionally Distinct Serotonergic Projections into Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Separable gain control of ongoing and evoked activity in the visual cortex by serotonergic input.eLife · 2020Article
- Mechanisms underlying gain modulation in the cortex.Nature reviews. Neuroscience · 2020Review
- Abnormal Functional Relationship of Sensorimotor Network With Neurotransmitter-Related Nuclei via Subcortical-Cortical Loops in Manic and Depressive Phases of Bipolar Disorder.Schizophrenia bulletin · 2020Article
- Opposite effects of dopamine and serotonin on resting-state networks: review and implications for psychiatric disorders.Molecular psychiatry · 2020Review
- Characterization of transgenic mouse models targeting neuromodulatory systems reveals organizational principles of the dorsal raphe.Nature communications · 2019Article
- Embracing diversity in the 5-HT neuronal system.Nature reviews. Neuroscience · 2019Review
- Overcoming Resistance to Selective Serotonin Reuptake Inhibitors: Targeting Serotonin, Serotonin-1A Receptors and Adult Neuroplasticity.Frontiers in neuroscience · 2019Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The inhibition of sensory responsivity is considered a core serotonin function, yet this hypothesis lacks direct support due to methodological obstacles. We adapted an optogenetic approach to induce acute, robust and specific firing of dorsal raphe serotonergic neurons. In vitro, the responsiveness of individual dorsal raphe serotonergic neurons to trains of light pulses varied with frequency and intensity as well as between cells, and the photostimulation protocol was therefore adjusted to maximize their overall output rate. In vivo, the photoactivation of dorsal raphe serotonergic neurons gave rise to a prominent light-evoked field response that displayed some sensitivity to a 5-HT1A agonist, consistent with autoreceptor inhibition of raphe neurons. In behaving mice, the photostimulation of dorsal raphe serotonergic neurons produced a rapid and reversible decrease in the animals' responses to plantar stimulation, providing a new level of evidence that serotonin gates sensory-driven responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.