Evidence map›Paper›PMID 25147953›Full record

ArticlePloS one2014

RecA protein plays a role in the chemotactic response and chemoreceptor clustering of Salmonella enterica.

Albert Mayola, Oihane Irazoki, Ignacio A Martínez, Dmitri Petrov, Filippo Menolascina, Roman Stocker, José A Reyes-Darias, Tino Krell, Jordi Barbé, Susana Campoy

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 29 citations in OpenAlex.

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  19. The Transient Multidrug Resistance Phenotype ofFrontiers in microbiology · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Albert MayolaDepartament de Genètica i de Microbiologia, Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Spain.
Oihane IrazokiDepartament de Genètica i de Microbiologia, Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Spain.
Ignacio A MartínezICFO-Institut de Ciències Fotòniques, Castelldefels, Spain.
Dmitri PetrovICFO-Institut de Ciències Fotòniques, Castelldefels, Spain.
Filippo MenolascinaDepartment of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.
Roman StockerDepartment of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.
José A Reyes-DariasDepartment of Environmental Protection, Estación Experimental del Zaidín-Consejo Superior de Investigaciones Científicas, Granada, Spain.
Tino KrellDepartment of Environmental Protection, Estación Experimental del Zaidín-Consejo Superior de Investigaciones Científicas, Granada, Spain.
Jordi BarbéDepartament de Genètica i de Microbiologia, Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Spain.
Susana CampoyDepartament de Genètica i de Microbiologia, Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Spain.
Universitat Autònoma de Barcelona · ESEstación Experimental del Zaidín · ESInstitute of Photonic Sciences · ESMassachusetts Institute of Technology · US

Funding

Transient behaviors of adapting biological systemsR01GM100473 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI SONTAG, EDUARDO · 2011 to 2014
$1.6M
NIGMS NIH HHS 1R01GM100473NIGMS NIH HHS R01 GM100473
6 · The paper itself

Abstract

The RecA protein is the main bacterial recombinase and the activator of the SOS system. In Escherichia coli and Salmonella enterica sv. Typhimurium, RecA is also essential for swarming, a flagellar-driven surface translocation mechanism widespread among bacteria. In this work, the direct interaction between RecA and the CheW coupling protein was confirmed, and the motility and chemotactic phenotype of a S. Typhimurium ΔrecA mutant was characterized through microfluidics, optical trapping, and quantitative capillary assays. The results demonstrate the tight association of RecA with the chemotaxis pathway and also its involvement in polar chemoreceptor cluster formation. RecA is therefore necessary for standard flagellar rotation switching, implying its essential role not only in swarming motility but also in the normal chemotactic response of S. Typhimurium.

Indexed as

Bacterial ProteinsChemotaxisFlagellaGene DeletionMutationProtein BindingRec A RecombinasesSalmonella entericaSalmonella typhimuriumBacterial ProteinsCheW protein, BacteriaRec A Recombinases

Identifiers

PMID25147953
PMCPMC4141790
OpenAlexW2055772273

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.