ArticlePloS one2014
Changes in cecal microbiota and mucosal gene expression revealed new aspects of epizootic rabbit enteropathy.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 102 citations in OpenAlex.
- Using Gut Microbiota and Gut Metabolites as Biomarkers for Diseases in Monogastric Farm Animals.Animals : an open access journal from MDPI · 2026Review
- Organic Acids in Rabbit Nutrition: Mechanisms, Advancements, and Potentials for Sustainable Production.Veterinary sciences · 2026Review
- Metagenomics reveals gut microbial differences and ecological adaptation in plateau zokor (Eospalax baileyi) populations.BMC microbiology · 2026Article
- Dual effects of probiotic administration prior to Mycobacterium avium subsp. paratuberculosis infection are associated with immunological and microbiota shifts.Scientific reports · 2025Article
- Effect of rabbit gastrointestinal stasis (RGIS) on the fecal microbiota of pet rabbits (Oryctolagus cuniculus).PloS one · 2025Article
- Dietary Mulberry leaf 1-deoxynijirimycin supplementation shortens villus height and improves intestinal barrier in fattening rabbits.Animal bioscience · 2024Article
- IngestingMicroorganisms · 2024Article
- Digestive problems in rabbit production: moving in the wrong direction?Frontiers in veterinary science · 2024Article
- Effects of Dietary Supplementation ofAnimals : an open access journal from MDPI · 2022Article
- Linking the bacterial microbiome between gut and habitat soil of Tibetan macaque (Ecology and evolution · 2022Article
- Digestive Tract Morphology and Gut Microbiota Jointly Determine an Efficient Digestive Strategy in Subterranean Rodents: Plateau Zokor.Animals : an open access journal from MDPI · 2022Article
- Effect of Feeding Insoluble Fiber on the Microbiota and Metabolites of the Caecum and Feces of Rabbits Recovering from Epizootic Rabbit Enteropathy Relative to Non-Infected Rabbits.Pathogens (Basel, Switzerland) · 2022Article
- The associations between intestinal bacteria of Eospalax cansus and soil bacteria of its habitat.BMC veterinary research · 2022Article
- Chlorogenic acid improves growth performance of weaned rabbitsFrontiers in microbiology · 2022Article
- Antibiotic removal does not affect cecal microbiota balance and productive parameters in LP robust rabbit line.Frontiers in veterinary science · 2022Article
- Oral administration of Moringa oleifera leaf powder relieves oxidative stress, modulates mucosal immune response and cecal microbiota after exposure to heat stress in New Zealand White rabbits.Journal of animal science and biotechnology · 2021Article
- Diverse methanogens, bacteria and tannase genes in the feces of the endangered volcano rabbit (PeerJ · 2021Article
- Breeding farm, level of feeding and presence of antibiotics in the feed influence rabbit cecal microbiota.Animal microbiome · 2020Article
- Metataxonomic and Histopathological Study of Rabbit Epizootic Enteropathy in Mexico.Animals : an open access journal from MDPI · 2020Article
- Dynamic distribution of gut microbiota in meat rabbits at different growth stages and relationship with average daily gain (ADG).BMC microbiology · 2020Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epizootic Rabbit Enteropathy (ERE) is a severe disease of unknown aetiology that mainly affects post-weaning animals. Its incidence can be prevented by antibiotic treatment suggesting that bacterial elements are crucial for the development of the disease. Microbial dynamics and host responses during the disease were studied. Cecal microbiota was characterized in three rabbit groups (ERE-affected, healthy and healthy pretreated with antibiotics), followed by transcriptional analysis of cytokines and mucins in the cecal mucosa and vermix by q-rtPCR. In healthy animals, cecal microbiota with or without antibiotic pretreatment was very similar and dominated by Alistipes and Ruminococcus. Proportions of both genera decreased in ERE rabbits whereas Bacteroides, Akkermansia and Rikenella increased, as well as Clostridium, γ-Proteobacteria and other opportunistic and pathogenic species. The ERE group displayed remarkable dysbiosis and reduced taxonomic diversity. Transcription rate of mucins and inflammatory cytokines was very high in ERE rabbits, except IL-2, and its analysis revealed the existence of two clearly different gene expression patterns corresponding to Inflammatory and (mucin) Secretory Profiles. Furthermore, these profiles were associated to different bacterial species, suggesting that they may correspond to different stages of the disease. Other data obtained in this work reinforced the notion that ERE morbidity and mortality is possibly caused by an overgrowth of different pathogens in the gut of animals whose immune defence mechanisms seem not to be adequately responding.
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