ArticleEpigenetics2014
Highly conserved ENY2/Sus1 protein binds to Drosophila CTCF and is required for barrier activity.
Article in Epigenetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Interaction of mRNA with the C-Terminal Domain of PCID2, a Subunit of the TREX-2 Complex, Is Required for Its Export from the Nucleus to the Cytoplasm in Drosophila melanogaster.Doklady. Biochemistry and biophysics · 2023Article
- Multiple Roles of dXNP and dADD1-International journal of molecular sciences · 2023Review
- Multi-Scale Organization of theGenes · 2021Review
- Study of dCTCF Insulator Activity in Drosophilamelanogaster Model Systems.Doklady. Biochemistry and biophysics · 2019Article
- Identification of the ORC Complex Subunits That Can Interact with the ENY2 Protein of Drosophila melanogaster.Doklady. Biochemistry and biophysics · 2018Article
- The Ubx Polycomb response element bypasses an unpaired Fab-8 insulator via cis transvection in Drosophila.PloS one · 2018Article
- Opbp is a new architectural/insulator protein required for ribosomal gene expression.Nucleic acids research · 2017Article
- Chromatin binding of Gcn5 in Drosophila is largely mediated by CP190.Nucleic acids research · 2017Article
- Functional Dissection of the Blocking and Bypass Activities of the Fab-8 Boundary in the Drosophila Bithorax Complex.PLoS genetics · 2016Article
- CTCF and Sgfl1 proteins form alternative complexes with ENY2 proteins.Doklady. Biochemistry and biophysics · 2016Article
- The boundary paradox in the Bithorax complex.Mechanisms of development · 2015Article
- Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functions.Development genes and evolution · 2015Article
- Functional role of dimerization and CP190 interacting domains of CTCF protein in Drosophila melanogaster.BMC biology · 2015Article
- The Functions and Mechanisms of Action of Insulators in the Genomes of Higher Eukaryotes.Acta naturaeArticle
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6 authors.
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Abstract
Chromatin insulators affect interactions between promoters and enhancers/silencers and function as barriers for the spreading of repressive chromatin. Drosophila insulator protein dCTCF marks active promoters and boundaries of many histone H3K27 trimethylation domains associated with repressed chromatin. In particular, dCTCF binds to such boundaries between the parasegment-specific regulatory domains of the Bithorax complex. Here we demonstrate that the evolutionarily conserved protein ENY2 is recruited to the zinc-finger domain of dCTCF and is required for the barrier activity of dCTCF-dependent insulators in transgenic lines. Inactivation of ENY2 by RNAi in BG3 cells leads to the spreading of H3K27 trimethylation and Pc protein at several dCTCF boundaries. The results suggest that evolutionarily conserved ENY2 is responsible for barrier activity mediated by the dCTCF protein.
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