Evidence map›Paper›PMID 25147783›Full record

ArticleFrontiers in public health2014

Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial.

Keith L Keene, Wei-Min Chen, Fang Chen, Stephen R Williams, Stacey D Elkhatib, Fang-Chi Hsu, Josyf C Mychaleckyj, Kimberly F Doheny, Elizabeth W Pugh, Hua Ling and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in public health, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. The Multitarget Action of Vitamins in the Ischemic Stroke.Current topics in medicinal chemistry · 2024
    Review
  6. Article
  7. Article
  8. Genetic determinants of low vitamin B12 levels in Alzheimer's disease risk.Alzheimer's & dementia (Amsterdam, Netherlands) · 2019
    Article
  9. Article
  10. Article
  11. Article
  12. A commonBlood · 2018
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 1 country.

Keith L KeeneCenter for Public Health Genomics, University of Virginia , Charlottesville, VA , USA ; Department of Biology, Center for Health Disparities, East Carolina University , Greenville, NC , USA.
Wei-Min ChenCenter for Public Health Genomics, University of Virginia , Charlottesville, VA , USA ; Department of Public Health Sciences, University of Virginia , Charlottesville, VA , USA.
Fang ChenCenter for Public Health Genomics, University of Virginia , Charlottesville, VA , USA.
Stephen R WilliamsCenter for Public Health Genomics, University of Virginia , Charlottesville, VA , USA.
Stacey D ElkhatibCenter for Public Health Genomics, University of Virginia , Charlottesville, VA , USA.
Fang-Chi HsuDepartment of Biostatistical Sciences, Wake Forest School of Medicine , Winston Salem, NC , USA.
Josyf C MychaleckyjCenter for Public Health Genomics, University of Virginia , Charlottesville, VA , USA ; Department of Public Health Sciences, University of Virginia , Charlottesville, VA , USA.
Kimberly F DohenyCenter for Inherited Disease Research, Johns Hopkins University School of Medicine , Baltimore, MD , USA.
Elizabeth W PughCenter for Inherited Disease Research, Johns Hopkins University School of Medicine , Baltimore, MD , USA.
Hua LingCenter for Inherited Disease Research, Johns Hopkins University School of Medicine , Baltimore, MD , USA.
Cathy C LaurieDepartment of Biostatistics, University of Washington , Seattle, WA , USA.
Stephanie M GogartenDepartment of Biostatistics, University of Washington , Seattle, WA , USA.
Ebony B MaddenNational Human Genome Research Institute, National Institutes of Health , Bethesda, MD , USA.
Bradford B WorrallDepartment of Public Health Sciences, University of Virginia , Charlottesville, VA , USA ; Department of Neurology, University of Virginia , Charlottesville, VA , USA.
Michele M SaleCenter for Public Health Genomics, University of Virginia , Charlottesville, VA , USA ; Department of Public Health Sciences, University of Virginia , Charlottesville, VA , USA ; Department of Biochemistry & Molecular Genetics, University of Virginia , Charlottesville, VA , USA.
University of Virginia · USJohns Hopkins Medicine · USUniversity of Washington · USEast Carolina University · USJohns Hopkins University · USNational Human Genome Research Institute · USWake Forest University · US

Funding

JH/CIDR Genotyping for Genome-Wide Association StudiesU01HG004438 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2007 to 2011
$24.2M
Vitamin Intervention for Stroke Prevention (VISP)R01NS034447 · NINDS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI TOOLE, JAMES F · 1996 to 2006
$18.0M
Randomized Clinical Trials - Whole Genome Studies Coordinating CenterU01HG005157 · NHGRI · UNIVERSITY OF WASHINGTON · PI HEAGERTY, PATRICK J, WEIR, BRUCE S. · 2009 to 2011
$2.4M
NHGRI NIH HHS U01 HG004438NHGRI NIH HHS U01 HG005157NINDS NIH HHS R01 NS034447
6 · The paper itself

Abstract

backgroundB vitamins play an important role in homocysteine metabolism, with vitamin deficiencies resulting in increased levels of homocysteine and increased risk for stroke. We performed a genome-wide association study (GWAS) in 2,100 stroke patients from the Vitamin Intervention for Stroke Prevention (VISP) trial, a clinical trial designed to determine whether the daily intake of high-dose folic acid, vitamins B6, and B12 reduce recurrent cerebral infarction.

methodsExtensive quality control (QC) measures resulted in a total of 737,081 SNPs for analysis. Genome-wide association analyses for baseline quantitative measures of folate, Vitamins B12, and B6 were completed using linear regression approaches, implemented in PLINK.

resultsSix associations met or exceeded genome-wide significance (P ≤ 5 × 10(-08)). For baseline Vitamin B12, the strongest association was observed with a non-synonymous SNP (nsSNP) located in the CUBN gene (P = 1.76 × 10(-13)). Two additional CUBN intronic SNPs demonstrated strong associations with B12 (P = 2.92 × 10(-10) and 4.11 × 10(-10)), while a second nsSNP, located in the TCN1 gene, also reached genome-wide significance (P = 5.14 × 10(-11)). For baseline measures of Vitamin B6, we identified genome-wide significant associations for SNPs at the ALPL locus (rs1697421; P = 7.06 × 10(-10) and rs1780316; P = 2.25 × 10(-08)). In addition to the six genome-wide significant associations, nine SNPs (two for Vitamin B6, six for Vitamin B12, and one for folate measures) provided suggestive evidence for association (P ≤ 10(-07)).

conclusionOur GWAS study has identified six genome-wide significant associations, nine suggestive associations, and successfully replicated 5 of 16 SNPs previously reported to be associated with measures of B vitamins. The six genome-wide significant associations are located in gene regions that have shown previous associations with measures of B vitamins; however, four of the nine suggestive associations represent novel finding and warrant further investigation in additional populations.

Indexed as

associationB12B6folateGWASone-carbon metabolismVISP

Identifiers

PMID25147783
PMCPMC4123605
OpenAlexW1969388040

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.