ArticleInternational journal of circumpolar health2014
Bioethical issues of preventing hereditary diseases with late onset in the Sakha Republic (Yakutia).
Article in International journal of circumpolar health, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- Assisted Reproductive Technologies and Oocyte Donation.Iranian journal of public health · 2025Article
- PGT-M for spinocerebellar ataxia type 1: development of a STR panel and a report of two clinical cases.Journal of assisted reproduction and genetics · 2024Article
- The attitude of young people in the city of Yakutsk to DNA-testing.International journal of circumpolar health · 2021Article
- A case-note review of continued pregnancies found to be at a high risk of Huntington's disease: considerations for clinical practice.European journal of human genetics : EJHG · 2019Review
- Genetic fitness and selection intensity in a population affected with high-incidence spinocerebellar ataxia type 1.Neurogenetics · 2016Article
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Authors and funding
6 authors at 3 institutions in 1 country.
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Abstract
backgroundPrenatal diagnosis of congenital and hereditary diseases is a priority for the development of medical technologies in Russia. However, there are not many published research results on bioethical issues of prenatal DNA testing.
objectiveThe main goal of the article is to describe some of the bioethical aspects of prenatal DNA diagnosis of hereditary diseases with late onset in genetic counselling practice in the Sakha Republic (Yakutia) - a far north-eastern region of Russia.
methodsThe methods used in the research are genetic counselling, invasive chorionic villus biopsy procedures, molecular diagnosis, social and demographic characteristics of patients.
resultsIn 10 years, 48 (76%) pregnant women from families tainted with hereditary spinocerebellar ataxia type 1 and 15 pregnant women from families with myotonic dystrophy have applied for medical and genetic counselling in order to undergo prenatal DNA testing. The average number of applications is 7-8 per year. There are differences in prenatal genetic counselling approaches.
conclusionIt is necessary to develop differentiated ethical approaches depending on the mode of inheritance, age of manifestation, and clinical polymorphism of hereditary disease.
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