Evidence map›Paper›PMID 25147725›Full record

ArticleJournal of healthcare engineering2012

Protein analytical assays for diagnosing, monitoring, and choosing treatment for cancer patients.

Alicia D Powers, Sean P Palecek

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of healthcare engineering, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 55 citations in OpenAlex.

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  14. KINOMIC ALTERATIONS IN ATYPICAL MENINGIOMA.Medical research archives · 2015
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alicia D PowersDepartment of Chemical and Biological Engineering University of Wisconsin-Madison.
Sean P PalecekDepartment of Chemical and Biological Engineering University of Wisconsin-Madison.
University of Wisconsin–Madison · US

Funding

Solid-state analysis of kinase activity in cell extractsR01GM074691 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI PALECEK, SEAN P · 2006 to 2010
$1.3M
NIGMS NIH HHS R01 GM074691
6 · The paper itself

Abstract

Cancer treatment is often hindered by inadequate methods for diagnosing the disease or insufficient predictive capacity regarding therapeutic efficacy. Targeted cancer treatments, including Bcr-Abl and EGFR kinase inhibitors, have increased survival for some cancer patients but are ineffective in other patients. In addition, many patients who initially respond to targeted inhibitor therapy develop resistance during the course of treatment. Molecular analysis of cancer cells has emerged as a means to tailor treatment to particular patients. While DNA analysis can provide important diagnostic information, protein analysis is particularly valuable because proteins are more direct mediators of normal and diseased cellular processes. In this review article, we discuss current and emerging protein assays for improving cancer treatment, including trends toward assay miniaturization and measurement of protein activity.

Indexed as

cancerdiagnosticmolecular diagnosticpersonalized cancer treatmentprotein assay

Identifiers

PMID25147725
PMCPMC4137876
OpenAlexW2067059191

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.