ReviewFood & nutrition research2014
Calcium and vitamin D supplementation: state of the art for daily practice.
Review in Food & nutrition research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 52 citations in OpenAlex.
- A phase IV, two-armed, randomized, cross-over study comparing compliance with once-a-month administration of vitamin D3 to compliance with daily administration of a fixed-dose combination of vitamin D3 and calcium during two 6-month periods.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Trial
- Analysis of Dissolution, Pharmacokinetic, and Bone-Protective Differences Among Calcium Formulations with Different Dosage Forms and Calcium Sources.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Review
- Prebiotics as modulators of colonic calcium and magnesium uptake.Acta physiologica (Oxford, England) · 2025Review
- Improving the diagnostic of absorptive hypercalciuria: a comparative analysis of calcium load tests at 2-hour and 4-hour intervals.Clinical kidney journal · 2025Article
- Article
- Evaluating adherence, tolerability and safety of oral calcium citrate in elderly osteopenic subjects: a real-life non-interventional, prospective, multicenter study.Aging clinical and experimental research · 2024Article
- Female Athlete Triad and Relative Energy Deficiency in Sport (REDs): Nutritional Management.Nutrients · 2024Review
- Is Dietary (Food) Supplement Intake Reported in European National Nutrition Surveys?Nutrients · 2023Review
- Article
- Advances in nutritional supplementation for sarcopenia management.Frontiers in nutrition · 2023Review
- Quercetin Regulates Calcium and Phosphorus Metabolism Through the Wnt Signaling Pathway in Broilers.Frontiers in veterinary science · 2021Article
- Response regarding the importance of vitamin D and calcium among undergraduate health sciences students in Al Kharj, Saudi Arabia.Archives of osteoporosis · 2020Article
- Intestinal CaWorld journal of gastroenterology · 2020Review
- Vitamin D testing: advantages and limits of the current assays.European journal of clinical nutrition · 2020Review
- Calcium citrate: from biochemistry and physiology to clinical applications.Reviews in endocrine & metabolic disorders · 2019Review
- Dietary Supplements and Cardiovascular Diseases.International journal of preventive medicine · 2018Review
- Clinical Identification of Geriatric Patients with Hypovitaminosis D: The 'Vitamin D Status Predictor for Geriatrics' Study.Nutrients · 2017Observational
- Oxidative stress, antioxidants and intestinal calcium absorption.World journal of gastroenterology · 2017Review
- Nutritional Aspects of Bone Health and Fracture Healing.Journal of osteoporosis · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCalcium and vitamin D play an essential role in bone metabolism but deficiency and/or inadequate intake are common.
objectivesTo describe a practical approach based on the literature regarding clinically important aspects of calcium and vitamin D supplementation.
methodsA systematic evaluation of relevant literature in Medline was conducted. We included physiological studies, publications on relevant guidelines, meta-analysis, randomized clinical trials, and cohort studies.
resultsAn adequate calcium intake and vitamin D supplementation is recommended in most guidelines xon fracture prevention. Daily supplementation with 800 IU is advocated in most guidelines, appears to be safe, and with this approach it is generally not necessary to determine vitamin D levels. There are no data on additional effects of loading doses of vitamin D on fracture or fall prevention. Calcium supplementation should be tailored to the patient's need: usually 500 mg per day is required. The intestinal absorption of calcium citrate is approximately 24% better than that of calcium carbonate independent of intake with meals. Data on difference between calcium absorption with calcium carbonate compared to calcium citrate with simultaneous use of proton pump inhibitors are lacking. Concern has arisen about a possible link between calcium supplementation and an increased risk of myocardial infarction. Probably only well-designed prospective randomized controlled trials will be able to allow definite conclusions on this subject.
conclusionDaily supplementation with 800 IU vitamin D is a practical and safe strategy without the need for prior determination of vitamin D levels. Calcium supplementation should be tailored to the patient's need based on total daily dietary calcium intake. In most patients 500 mg per day is required to achieve a total intake of 1,200 mg, or in some 1,000 mg per day. More calcium is absorbed from calcium citrate compared to calcium carbonate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.