Evidence map›Paper›PMID 25147414›Full record

ArticleCarbohydrate polymers2010

Identification of a novel structure in heparin generated by potassium permanganate oxidation.

Daniela Beccati, Sucharita Roy, Fei Yu, Nur Sibel Gunay, Ishan Capila, Miroslaw Lech, Robert J Linhardt, Ganesh Venkataraman

Abstract read
In one paragraph

Article in Carbohydrate polymers, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 26 citations in OpenAlex.

  1. Bioengineered production of glycosaminoglycans and their analogues.Systems microbiology and biomanufacturing · 2021
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. General Considerations for Diversifying Heparin Drug Products by Improving the Current Heparin Manufacturing Process and Reintroducing Bovine Sourced Heparin to the US Market.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Daniela BeccatiMomenta Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA.
Sucharita RoyMomenta Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA.
Fei YuMomenta Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA.
Nur Sibel GunayMomenta Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA.
Ishan CapilaMomenta Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA.
Miroslaw LechMomenta Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA.
Robert J LinhardtDepartments of Chemistry and Chemical Biology, Biology, and Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Center for Biotechnology and Interdisciplinary Studies, 110 8th Street, Troy, NY 12180, USA.
Ganesh VenkataramanMomenta Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA.
Momenta Pharmaceuticals (United States) · USRensselaer Polytechnic Institute · US

Funding

SEQUENCING THE POLYSACCHARIDE COMPONENT OF PROTEOGLYCANSR01GM038060 · NIGMS · UNIVERSITY OF IOWA · PI LINHARDT, ROBERT J · 1988 to 2012
$2.8M
NIGMS NIH HHS R01 GM038060
6 · The paper itself

Abstract

The worldwide heparin contamination crisis in 2008 led health authorities to take fundamental steps to better control heparin manufacture, including implementing appropriate analytical and bio-analytical methods to ensure production and release of high quality heparin sodium product. Consequently, there is an increased interest in the identification and structural elucidation of unusually modified structures that may be present in heparin. Our study focuses on the structural elucidation of species that give rise to a signal observed at 2.10 ppm in the

Indexed as

1H NMRHeparinHSQCN-AcetylglucosamineOxidationPermanganateReducing end

Identifiers

PMID25147414
PMCPMC4138061
OpenAlexW2106921203

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.