Evidence map›Paper›PMID 25147325›Full record

ArticleClinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis2015

Levels of soluble TREM-like transcript 1 in patients presenting to the emergency department with chest pain.

Omar L Esponda, Robert Hunter, José R Rivera Del Río, A Valance Washington

Open access · greenAbstract read
In one paragraph

Article in Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact, top 85% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
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  5. Frontiers in immunology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Omar L EspondaDepartment of Internal Medicine, Hospital Universitario Dr Ramón Ruiz Arnau, Universidad Central del Caribe, Bayamón, PR, USA.
Robert HunterDepartment of Internal Medicine, Hospital Universitario Dr Ramón Ruiz Arnau, Universidad Central del Caribe, Bayamón, PR, USA Laboratory of Anatomy and Cell Biology, Hospital HIMA San Pablo, Bayamón, PR, USA.
José R Rivera Del RíoDepartment of Internal Medicine, Hospital Universitario Dr Ramón Ruiz Arnau, Universidad Central del Caribe, Bayamón, PR, USA Laboratory of Anatomy and Cell Biology, Hospital HIMA San Pablo, Bayamón, PR, USA.
A Valance WashingtonDepartment of Biology, University of Puerto Rico-Rio Piedras, San Juan, PR, USA valancew@gmail.com.
Central University of the Caribbean · PRUniversity of Puerto Rico at Río Piedras · PR

Funding

UNIVERSITY MEDICAL RESEARCH CENTERG12RR003035 · NCRR · UNIVERSIDAD CENTRAL DEL CARIBE · PI ROJAS, LEGIER V · 1986 to 2011
$26.7M
TECHNOLOGIES AND RESOURCES FOR CORE LABORATORIESU54MD007587 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI LUCIANO, CARLOS A., NOBOA, CARIAMARIE · 2012 to 2018
$23.2M
UNIVERSIDAD CENTRAL DEL CARIBE BIOMEDICAL RESEARCH CENTERSG12MD007583 · NIMHD · UNIVERSIDAD CENTRAL DEL CARIBE · PI RODRIGUEZ, JOSE GINEL · 2012 to 2016
$8.4M
Translation Studies of the Planet Specific Receptor Trem Like Transcript (TLT)R01HL090933 · NHLBI · UNIVERSITY OF PUERTO RICO RIO PIEDRAS · PI WASHINGTON, A. VALANCE · 2011 to 2022
$2.9M
NCRR NIH HHS G12 RR003035NCRR NIH HHS G12RR-03035NHLBI NIH HHS 1R01HL090933NHLBI NIH HHS R01 HL090933NIMHD NIH HHS 8U54MD007587-03NIMHD NIH HHS G12 MD007583
6 · The paper itself

Abstract

objectiveRecent studies suggest that the soluble triggering receptor expressed on myeloid cells-like transcript 1 (sTLT-1) facilitate atherothrombosis. Therefore, we evaluated sTLT-1 as a functional measure of atherothrombosis in acute coronary syndrome (ACS).

methodsLevels of sTLT-1 were determined by enzyme-linked immunosorbent assay on plasma from patients with potential ACS and compared with an age-matched control group with similar risk factors for cardiovascular disease.

resultsOf 53 patients enrolled, 19 patients were undergoing ACS (15 unstable angina, 2 non-ST-segment elevated myocardial infarction, and 2 ST-segment elevated myocardial infarction), 5 patients were found with noncardiac chest pain, and 29 were in the control group. The mean plasma sTLT-1 values in the ACS group were 4.644 ng/mL ± 1.277 standard error of the mean (SEM), in the noncardiac chest pain group were 0.708 ng/mL ± 0.427 SEM, and in the control group were 1.007 ng/mL ± 0.098 SEM.

conclusionA statistically significant difference exists between patients experiencing cardiogenic chest pain versus controls (P < .05), suggesting sTLT-1 as a potential tool for understanding atherothrombosis in ACS.

Indexed as

Acute Coronary SyndromeAgedAged, 80 and overBiomarkersBlood PlateletsCase-Control StudiesChest PainCoronary Artery DiseaseEmergency Service, HospitalFemaleHumansInflammation MediatorsMaleMiddle AgedReceptors, ImmunologicRisk FactorsBiomarkersInflammation MediatorsReceptors, ImmunologicTREML1 protein, humanacute coronary syndromesatherosclerosiscardiologylupus inhibitorsTLT-1TREM

Identifiers

PMID25147325
PMCPMC4356632
OpenAlexW2143669675

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.