Evidence map›Paper›PMID 25147253›Full record

Trial reportDiabetes care2014

Impact of an intensive lifestyle intervention on use and cost of medical services among overweight and obese adults with type 2 diabetes: the action for health in diabetes.

Mark A Espeland, Henry A Glick, Alain Bertoni, Frederick L Brancati, George A Bray, Jeanne M Clark, Jeffrey M Curtis, Caitlin Egan, Mary Evans, John P Foreyt and 35 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes care, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

45 authors.

Mark A EspelandDepartment of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC mespelan@wakehealth.edu.
Henry A GlickWeight and Eating Disorder Program, University of Pennsylvania, Philadelphia, PA.
Alain BertoniDepartment of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC.
Frederick L BrancatiJohns Hopkins School of Medicine, Baltimore, MD.
George A BrayPennington Biomedical Research Center, Baton Rouge, LA.
Jeanne M ClarkJohns Hopkins School of Medicine, Baltimore, MD.
Jeffrey M CurtisSouthwest American Indian Center, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ Southwest American Indian Center, National Institute of Diabetes and Digestive and Kidney Diseases, Shiprock, NM.
Caitlin EganWeight Control and Diabetes Research Center, Brown Medical School/The Miriam Hospital, Providence, RI.
Mary EvansNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
John P ForeytDepartment of Medicine, Baylor College of Medicine, Houston, TX.
Siran GhazarianRoybal Comprehensive Health Center, Los Angeles, CA.
Edward W GreggCenters for Disease Control and Prevention, Atlanta, GA.
Helen P HazudaUniversity of Texas Health Science Center at San Antonio, San Antonio, TX.
James O HillAnschutz Health and Wellness Center, University of Colorado Health Sciences Center, Aurora, CO.
Don HireDepartment of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC.
Edward S HortonDepartment of Clinical Epidemiology, Joslin Diabetes Center, Boston, MA.
Van S HubbardNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
John M JakicicDiabetes Unit, Department of Health and Physical Activity, University of Pittsburgh, Pittsburgh, PA.
Robert W JefferyDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN.
Karen C JohnsonDepartment of Preventive Medicine, University of Tennessee Health Sciences Center, Memphis, TN.
Steven E KahnDepartment of Medicine, University of Washington, Seattle, WA.
Tina KilleanSouthwest American Indian Center, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ Southwest American Indian Center, National Institute of Diabetes and Digestive and Kidney Diseases, Shiprock, NM.
Abbas E KitabchiDepartment of Preventive Medicine, University of Tennessee Health Sciences Center, Memphis, TN.
William C KnowlerSouthwest American Indian Center, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ Southwest American Indian Center, National Institute of Diabetes and Digestive and Kidney Diseases, Shiprock, NM.
Andrea KriskaDiabetes Unit, Department of Health and Physical Activity, University of Pittsburgh, Pittsburgh, PA.
Cora E LewisPreventive Medicine, University of Alabama at Birmingham, Birmingham, AL.
Marsha MillerAnschutz Health and Wellness Center, University of Colorado Health Sciences Center, Aurora, CO.
Maria G MontezUniversity of Texas Health Science Center at San Antonio, San Antonio, TX.
Anne MurilloDepartment of Medicine, University of Washington, Seattle, WA.
David M NathanMassachusetts General Hospital, Boston, MA.
Ebenezer NyenweDepartment of Preventive Medicine, University of Tennessee Health Sciences Center, Memphis, TN.
Jennifer PatricioDivision of and Department of Medicine, St. Luke's-Roosevelt Hospital, New York, NY.
Anne L PetersRoybal Comprehensive Health Center, Los Angeles, CA.
Xavier Pi-SunyerDivision of and Department of Medicine, St. Luke's-Roosevelt Hospital, New York, NY.
Henry PownallDepartment of Medicine, Baylor College of Medicine, Houston, TX.
J Bruce RedmonDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN.
Julia RushingDepartment of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC.
Donna H RyanPennington Biomedical Research Center, Baton Rouge, LA.
Monika SaffordPreventive Medicine, University of Alabama at Birmingham, Birmingham, AL.
Adam G TsaiDivision of Internal Medicine, University of Colorado Health Sciences Center, Aurora, CO.
Thomas A WaddenWeight and Eating Disorder Program, University of Pennsylvania, Philadelphia, PA.
Rena R WingWeight Control and Diabetes Research Center, Brown Medical School/The Miriam Hospital, Providence, RI.
Susan Z YanovskiNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD.
Ping ZhangCenters for Disease Control and Prevention, Atlanta, GA.
Look AHEAD Research Group

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Julie Mathieu · 1986 to 2026
$41.4M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Stuart J Frank · 2013 to 2026
$19.5M
STUDY OF HEALTH OUTCOMES OF WEIGHT-LOSS (SHOW)U01DK057149 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI CLARK, JEANNE M · 1999 to 2020
$17.4M
Institute for Integration of Medicine & Science: A Partnership to Improve HealthUL1TR001120 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CLARK, ROBERT A, HARGREAVES, KENNETH M · 2013 to 2017
$16.5M
Understanding Obesity In Relation to the Built EnvironmentP20MD006899 · NIMHD · JACKSON STATE UNIVERSITY · PI ADDISON, CLIFTON · 2012 to 2016
$5.3M
Weight loss in the treatment of type 2 diabetesZIADK075077 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI KNOWLER, WILLIAM C · 2012 to 2021
$2.5M
Beta-cell ProliferationR01DK081472 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI HUSSAIN, MEHBOOB A, WONDISFORD, FREDRIC E. · 2009 to 2013
$2.1M
NCATS NIH HHS UL1 TR001120NIDDK NIH HHS P30 DK017047NIDDK NIH HHS P30 DK079626NIDDK NIH HHS R01 DK081472NIDDK NIH HHS U01 DK057149NIMHD NIH HHS P20 MD006899
6 · The paper itself

Abstract

objectiveTo assess the relative impact of an intensive lifestyle intervention (ILI) on use and costs of health care within the Look AHEAD trial. RESEARCH DESIGN AND

methodsA total of 5,121 overweight or obese adults with type 2 diabetes were randomly assigned to an ILI that promoted weight loss or to a comparison condition of diabetes support and education (DSE). Use and costs of health-care services were recorded across an average of 10 years.

resultsILI led to reductions in annual hospitalizations (11%, P = 0.004), hospital days (15%, P = 0.01), and number of medications (6%, P < 0.001), resulting in cost savings for hospitalization (10%, P = 0.04) and medication (7%, P < 0.001). ILI produced a mean relative per-person 10-year cost savings of $5,280 (95% CI 3,385-7,175); however, these were not evident among individuals with a history of cardiovascular disease.

conclusionsCompared with DSE over 10 years, ILI participants had fewer hospitalizations, fewer medications, and lower health-care costs.

Indexed as

Health Care CostsLife StyleAdultAgedCardiovascular DiseasesDiabetes Mellitus, Type 2FemaleFollow-Up StudiesHealth ServicesHumansMaleMiddle AgedObesityOverweightSingle-Blind Method

Identifiers

PMID25147253
PMCPMC4140155

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.