ArticleNucleic acids research2014
A 'tool box' for deciphering neuronal circuits in the developing chick spinal cord.
Article in Nucleic acids research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
- Temporal control of midline crossing via incoherent feedforward and feedback loops regulating Robo3.iScience · 2026Article
- Temporal control of axonal floor plate crossing through a combination of incoherent feedforward and feedback loops of gene regulatory network regulating Robo3 expression.bioRxiv : the preprint server for biology · 2025Article
- NeuroLab 2.0: An Alternative Storyline Design Approach for Translating a Research-Based Summer Experience into an Advanced STEM+M Curriculum Unit that Supports Three-Dimensional Teaching and Learning in the Classroom.Journal of STEM outreach · 2024Article
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- Axon guidance at the spinal cord midline-A live imaging perspective.The Journal of comparative neurology · 2021Article
- Natural loss of function of ephrin-B3 shapes spinal flight circuitry in birds.Science advances · 2021Article
- Axonal Projection Patterns of the Dorsal Interneuron Populations in the Embryonic Hindbrain.Frontiers in neuroanatomy · 2021Review
- Temporal-specific roles of fragile X mental retardation protein in the development of the hindbrain auditory circuit.Development (Cambridge, England) · 2020Article
- NeuroLab Research Experiences: Extending the CURE Design Framework into an Informal Science Setting Dedicated to Pre-College STEM Instruction.Journal of STEM outreach · 2019Article
- Article
- Neural stem cells deriving from chick embryonic hindbrain recapitulate hindbrain development in culture.Scientific reports · 2018Article
- Shaping the Output of Lumbar Flexor Motoneurons by Sacral Neuronal Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Modified mRNA as a therapeutic tool to induce cardiac regeneration in ischemic heart disease.Wiley interdisciplinary reviews. Systems biology and medicine · 2017Review
- Mosaic Expression of Thyroid Hormone Regulatory Genes Defines Cell Type-Specific Dependency in the Developing Chicken Cerebellum.Cerebellum (London, England) · 2016Article
- Making sense out of spinal cord somatosensory development.Development (Cambridge, England) · 2016Review
- Foxp1-mediated programming of limb-innervating motor neurons from mouse and human embryonic stem cells.Nature communications · 2015Article
- Control of axon guidance and neurotransmitter phenotype of dB1 hindbrain interneurons by Lim-HD code.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- The sacral networks and neural pathways used to elicit lumbar motor rhythm in the rodent spinal cord.Frontiers in neural circuits · 2014Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genetic dissection of spinal circuits is an essential new means for understanding the neural basis of mammalian behavior. Molecular targeting of specific neuronal populations, a key instrument in the genetic dissection of neuronal circuits in the mouse model, is a complex and time-demanding process. Here we present a circuit-deciphering 'tool box' for fast, reliable and cheap genetic targeting of neuronal circuits in the developing spinal cord of the chick. We demonstrate targeting of motoneurons and spinal interneurons, mapping of axonal trajectories and synaptic targeting in both single and populations of spinal interneurons, and viral vector-mediated labeling of pre-motoneurons. We also demonstrate fluorescent imaging of the activity pattern of defined spinal neurons during rhythmic motor behavior, and assess the role of channel rhodopsin-targeted population of interneurons in rhythmic behavior using specific photoactivation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.