ArticleG3 (Bethesda, Md.)2014
A saturated genetic linkage map of autotetraploid alfalfa (Medicago sativa L.) developed using genotyping-by-sequencing is highly syntenous with the Medicago truncatula genome.
Article in G3 (Bethesda, Md.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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56 citing papers in PubMed, 101 citations in OpenAlex.
- Enhancing alfalfa breeding through genomic prediction with exotic germplasm resources.BMC plant biology · 2026Article
- Breeding of a Multifoliolate Alfalfa Population Using CRISPR/Cas9-Generated Mutants and Evaluation of Agronomic Traits and Nutritive Value.Plants (Basel, Switzerland) · 2026Article
- Exploring the genetic diversity of the IPK Medicago germplasm collection using GBS.Plant biology (Stuttgart, Germany) · 2026Article
- QTL detection and genomic prediction for resistance to anthracnose in alfalfa (Medicago sativa).The plant genome · 2025Article
- Allotetraploid Origin and Putative Ancient Introgression inEcology and evolution · 2025Article
- Graph-Based Pangenome of Actinidia chinensis Reveals Structural Variations Mediating Fruit Degreening.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- To be or not to be tetraploid-the impact of marker ploidy on genomic prediction and GWAS of potato.Frontiers in plant science · 2024Article
- Temperature increase modifies susceptibility to Verticillium wilt inFrontiers in plant science · 2023Article
- Genome-wide genotyping data renew knowledge on genetic diversity of a worldwide alfalfa collection and give insights on genetic control of phenology traits.Frontiers in plant science · 2023Article
- Alfalfa genomic selection for different stress-prone growing regions.The plant genome · 2022Article
- OMICS in Fodder Crops: Applications, Challenges, and Prospects.Current issues in molecular biology · 2022Review
- Combining QTL mapping and RNA-Seq Unravels candidate genes for Alfalfa (Medicago sativa L.) leaf development.BMC plant biology · 2022Article
- Genomic prediction for canopy height and dry matter yield in alfalfa using family bulks.The plant genome · 2022Article
- Transcriptome Analysis ofGenes · 2022Article
- Identification of QTL and candidate genes associated with biomass yield and Feed Quality in response to water deficit in alfalfa (Frontiers in plant science · 2022Article
- RAD-Seq-Based High-Density Linkage Maps Construction and Quantitative Trait Loci Mapping of Flowering Time Trait in Alfalfa (Frontiers in plant science · 2022Article
- Mapping freezing tolerance QTL in alfalfa: based on indoor phenotyping.BMC plant biology · 2021Article
- A consensus and saturated genetic map provides insight into genome anchoring, synteny of Solanaceae and leaf- and fruit-related QTLs in wolfberry (Lycium Linn.).BMC plant biology · 2021Article
- Identification of Genetic Loci Associated With Crude Protein Content and Fiber Composition in Alfalfa (Frontiers in plant science · 2021Article
- Genome-Wide Association Studies Identifying Multiple Loci Associated With Alfalfa Forage Quality.Frontiers in plant science · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A genetic linkage map is a valuable tool for quantitative trait locus mapping, map-based gene cloning, comparative mapping, and whole-genome assembly. Alfalfa, one of the most important forage crops in the world, is autotetraploid, allogamous, and highly heterozygous, characteristics that have impeded the construction of a high-density linkage map using traditional genetic marker systems. Using genotyping-by-sequencing (GBS), we constructed low-cost, reasonably high-density linkage maps for both maternal and paternal parental genomes of an autotetraploid alfalfa F1 population. The resulting maps contain 3591 single-nucleotide polymorphism markers on 64 linkage groups across both parents, with an average density of one marker per 1.5 and 1.0 cM for the maternal and paternal haplotype maps, respectively. Chromosome assignments were made based on homology of markers to the M. truncatula genome. Four linkage groups representing the four haplotypes of each alfalfa chromosome were assigned to each of the eight Medicago chromosomes in both the maternal and paternal parents. The alfalfa linkage groups were highly syntenous with M. truncatula, and clearly identified the known translocation between Chromosomes 4 and 8. In addition, a small inversion on Chromosome 1 was identified between M. truncatula and M. sativa. GBS enabled us to develop a saturated linkage map for alfalfa that greatly improved genome coverage relative to previous maps and that will facilitate investigation of genome structure. GBS could be used in breeding populations to accelerate molecular breeding in alfalfa.
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