Evidence map›Paper›PMID 25147155›Full record

Trial reportClinical journal of the American Society of Nephrology : CJASN2014

Effect of increasing dietary fiber on plasma levels of colon-derived solutes in hemodialysis patients.

Tammy L Sirich, Natalie S Plummer, Christopher D Gardner, Thomas H Hostetter, Timothy W Meyer

3 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical journal of the American Society of Nephrology : CJASN, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 165 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
165citing papers in PubMed, 12 pooled it
10.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02976688 phase2 / phase3unknown statusnot on this mapstarted 2017, after this paper: background citation

Effects of Short-chain Fatty Acids, Here Sodium Propionate, a Metabolism Product of the Human Gut-microbiome, on Inflammatory and Metabolic Parameters in Patients on Maintenance Hemodialysis - a Pilot Study

TypeinterventionalSponsorAzienda Sanitaria ASL Avellino 2Ran2017 to 2017Enrolled15ConditionsEndstage Renal DiseaseArmsSodium Propionate
NCT04527640 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Effects of Synbiotics Supplementation on the Concentration of the Uremic Toxin Indoxyl Sulfate, Symptoms of Constipation, and Constipation-related Quality of Life in End-stage Renal Disease Patients Undergoing Hemodialysis

TypeinterventionalSponsorIndonesia UniversityRan2020 to 2021Enrolled60ConditionsConstipation, End Stage Renal Disease on DialysisArmsSynbiotics containing Lactobacillus acidophilus & Bifidobacterium longum 5x10^9 CFU and FOS 60 mg, Placebo
NCT05312788 nacompletednot on this mapstarted 2022, after this paper: background citation

Effect of Barley Supplemented Wheat Bread on Markers of Cardiovascular and Renal Health: A Randomized Controlled Trial

TypeinterventionalSponsorKhyber Medical University PeshawarRan2022 to 2022Enrolled25ConditionsCardiovascular Diseases, Kidney DiseasesArmsEffect of Barley Supplemented Wheat Bread on markers of Cardiovascular and Renal Health
3 · Its place in the literature

Who cites it

165 citing papers in PubMed, 12 syntheses or guidelines pooled it, 287 citations in OpenAlex.

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  7. Biotic Supplements in Patients With Chronic Kidney Disease: Meta-Analysis of Randomized Controlled Trials.Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation · 2022
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105 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Tammy L SirichDepartments of Medicine, Veterans Affairs Palo Alto Health Care System and Stanford University, Palo Alto, California; and tsirich@stanford.edu.
Natalie S PlummerDepartments of Medicine, Veterans Affairs Palo Alto Health Care System and Stanford University, Palo Alto, California; and.
Christopher D GardnerDepartments of Medicine, Veterans Affairs Palo Alto Health Care System and Stanford University, Palo Alto, California; and.
Thomas H HostetterDepartment of Medicine, Case Western Reserve University, Cleveland, Ohio.
Timothy W MeyerDepartments of Medicine, Veterans Affairs Palo Alto Health Care System and Stanford University, Palo Alto, California; and.
Stanford University · USCase Western Reserve University · US

Funding

Spectrum Stanford Center for clinical and Translational Research and EducationUL1TR001085 · NCATS · STANFORD UNIVERSITY · PI CULLEN, MARK RICHARD, GREENBERG, HARRY BERNARD · 2013 to 2017
$37.1M
Stanford Center for Clinical and Translational Education and Research (SCCTER)UL1UL1TR000093 · NCATS · STANFORD UNIVERSITY · PI GREENBERG, HARRY BERNARD · 2012 to 2013
$6.5M
TRAINING PROGRAM IN ACADEMIC NEPHROLOGYT32DK007357 · NIDDK · STANFORD UNIVERSITY · PI CHERTOW, GLENN MATTHEW · 1986 to 2022
$4.8M
Dietary Maneuvers to Reduce Production of Colon-Derived Uremic SolutesR21AT005123 · NCCIH · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI MEYER, TIMOTHY W · 2010 to 2011
$582k
NCATS NIH HHS UL1 TR000093NCATS NIH HHS UL1-TR000093NCATS NIH HHS UL1 TR001085NCCIH NIH HHS R21 AT005123NIDDK NIH HHS T32 DK007357
6 · The paper itself

Abstract

BACKGROUND AND

objectivesNumerous uremic solutes are derived from the action of colon microbes. Two such solutes, indoxyl sulfate and p-cresol sulfate, have been associated with adverse outcomes in renal failure. This study tested whether increasing dietary fiber in the form of resistant starch would lower the plasma levels of these solutes in patients on hemodialysis. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Fifty-six patients on maintenance hemodialysis were randomly assigned to receive supplements containing resistant starch (n=28) or control starch (n=28) daily for 6 weeks in a study conducted between October 2010 and May 2013. Of these, 40 patients (20 in each group) completed the study and were included in the final analysis. Plasma indoxyl sulfate and p-cresol sulfate levels were measured at baseline and week 6.

resultsIncreasing dietary fiber for 6 weeks significantly reduced the unbound, free plasma level of indoxyl sulfate (median -29% [25th percentile, 75th percentile, -56, -12] for fiber versus -0.4% [-20, 34] for control, P=0.02). The reduction in free plasma levels of indoxyl sulfate was accompanied by a reduction in free plasma levels of p-cresol sulfate (r=0.81, P<0.001). However, the reduction of p-cresol sulfate levels was of lesser magnitude and did not achieve significance (median -28% [-46, 5] for fiber versus 4% [-28, 36] for control, P=0.05).

conclusionsIncreasing dietary fiber in hemodialysis patients may reduce the plasma levels of the colon-derived solutes indoxyl sulfate and possibly p-cresol sulfate without the need to intensify dialysis treatments. Further studies are required to determine whether such reduction provides clinical benefits.

Indexed as

Renal DialysisColonCresolsDietary FiberFemaleHumansIndicanMaleMiddle AgedProspective StudiesSingle-Blind MethodSulfuric Acid Esters4-cresol sulfateCresolsDietary FiberIndicanSulfuric Acid Esterschronic hemodialysisintestinenutritionuremia

Identifiers

PMID25147155
PMCPMC4152802
OpenAlexW2096876421

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.