ArticleInternational journal of colorectal disease2014
Prognostic value of preoperative D-dimer and carcinoembryonic antigen levels in patients undergoing intended curative resection for colorectal cancer: a prospective cohort study.
Article in International journal of colorectal disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- High pretreatment plasma D-dimer levels predict poor prognosis in gastrointestinal cancers: A meta-analysis.Medicine · 2019Pooled it
- Prognostic value of preoperative D-dimer to albumin ratio in patients with locally advanced rectal cancer after neoadjuvant chemoradiotherapy.Discover oncology · 2024Article
- Prognostic value of coagulation markers in patients with colorectal caner: A prospective study.Health science reports · 2024Article
- D-dimer to lymphocyte ratio can serve as a potential predictive and prognostic value in colorectal cancer patients with liver metastases.BMC surgery · 2023Article
- Prothrombin time (PT) and CEA as prognostic predictive biomarkers for postoperative recurrence after curative resection in patients with stage I-III colorectal cancer: a retrospective cohort study.Updates in surgery · 2022Article
- Application Value of Combined Detection of NLR, PNI, D-Dimer, CD3Disease markers · 2022Article
- Significance of preoperative blood tests in the prognosis of colorectal cancer: A prospective, multicenter study from Hungary.Journal of clinical laboratory analysis · 2022Article
- Proteomic Characterization of Colorectal Cancer Cells versus Normal-Derived Colon Mucosa Cells: Approaching Identification of Novel Diagnostic Protein Biomarkers in Colorectal Cancer.International journal of molecular sciences · 2020Article
- Association between D-Dimer Levels and the Prognosis of Terminal Cancer Patients in the Last Hours of Life.Han'guk Hosup'isu Wanhwa Uiryo Hakhoe chi = The Korean journal of hospice and palliative care · 2020Article
- Prognostic significance of pretreatment plasma D-dimer levels in patients with spinal chordoma: a retrospective cohort study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2019Article
- D-dimer predicts postoperative recurrence and prognosis in patients with liver metastasis of colorectal cancer.International journal of clinical oncology · 2018Article
- Usefulness of plasma D-dimer level for monitoring development of distant organ metastasis in colorectal cancer patients after curative resection.Cancer management and research · 2018Article
- Circulating D-dimer level correlates with disease characteristics in hepatoblastoma patients.Medicine · 2017Article
- High pretreatment plasma D-dimer predicts poor survival of colorectal cancer: insight from a meta-analysis of observational studies.Oncotarget · 2017Article
- Preoperative plasma fibrinogen, but not D-dimer might represent a prognostic factor in non-metastatic colorectal cancer: A prospective cohort study.Cancer biomarkers : section A of Disease markers · 2017Article
- Prognostic Role of Preoperative D-dimer Levels in Patients With Stage I-III Colorectal Cancer.Cancer diagnosis & prognosisArticle
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4 authors.
Funding
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Abstract
purposeCarcinoembryonic antigen (CEA) has limited value as an isolated predictor for survival among colorectal cancer (CRC) patients. D-dimer (DD) is a strong predictor of survival among metastatic CRC patients, but the prognostic value in non-metastatic CRC patients remains controversial. We examined the prognostic value of preoperative DD levels in relation to CEA levels in non-metastatic, resectable CRC patients.
methodsBetween October 2003 and November 2005, 166 patients were included. We used the Kaplan-Meier method to compute 5-year mortality rates, stratified by preoperative DD and CEA levels. Adjusted Cox regression analysis was used to compute mortality rate ratios (MRRs) during postoperative years 0-1 and 1-5 based on the preoperative CEA and DD levels.
resultsThe cumulative 5-year mortality rate was 15 % (95 % confidence interval [CI], 9-25 %) in patients with normal DD and CEA levels, 30 % (CI, 16-53 %) in patients with isolated elevated CEA levels, 37 % (CI, 25-53 %) in patients with isolated elevated DD levels, and 60 % (CI, 37-83 %) in patients with elevated CEA and DD levels. Elevated CEA was associated with an approximately ten-fold increase in mortality within the first postoperative year (adjusted MRR 9.8, CI 2.5-38.3); this association was lost during postoperative years 1-5 (adjusted MRR 1.1, CI 0.5-2.7). Elevated DD was associated with a greater than two-fold increase in mortality during postoperative years 0-1 (adjusted MRR 2.8, CI 0.7-11.0) and 1-5 (adjusted MRR 2.2, CI 1.1-4.8).
conclusionDD is a strong predictor of survival among non-metastatic curatively resected CRC patients, particularly in combination with CEA.
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