ArticleScientific reports2014
Tissue-specific mechanical and geometrical control of cell viability and actin cytoskeleton alignment.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 38 citations in OpenAlex.
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- Microarchitected Compliant Scaffolds of Pyrolytic Carbon for 3D Muscle Cell Growth.Advanced healthcare materials · 2024Article
- Vibration acceleration enhances proliferation, migration, and maturation of C2C12 cells and promotes regeneration of muscle injury in male rats.Physiological reports · 2024Article
- Biomechanical, biophysical and biochemical modulators of cytoskeletal remodelling and emergent stem cell lineage commitment.Communications biology · 2023Review
- 3D Microwell Platforms for Control of Single Cell 3D Geometry and Intracellular Organization.Cellular and molecular bioengineering · 2021Article
- Cell alignment and accumulation using acoustic nozzle for bioprinting.Scientific reports · 2019Article
- Matrix stiffness modulates the differentiation of neural crest stem cells in vivo.Journal of cellular physiology · 2019Article
- Live cell imaging reveals focal adhesions mechanoresponses in mammary epithelial cells under sustained equibiaxial stress.Scientific reports · 2018Article
- Adult Stem Cells in Vascular Remodeling.Theranostics · 2018Review
- Gtf2ird1-Dependent Mohawk Expression Regulates Mechanosensing Properties of the Tendon.Molecular and cellular biology · 2016Article
- Patterning of Fibroblast and Matrix Anisotropy within 3D Confinement is Driven by the Cytoskeleton.Advanced healthcare materials · 2016Article
- Nuclear deformability and telomere dynamics are regulated by cell geometric constraints.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Contractility of single cardiomyocytes differentiated from pluripotent stem cells depends on physiological shape and substrate stiffness.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- High-content imaging with micropatterned multiwell plates reveals influence of cell geometry and cytoskeleton on chromatin dynamics.Biotechnology journal · 2015Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Different tissues have specific mechanical properties and cells of different geometries, such as elongated muscle cells and polygonal endothelial cells, which are precisely regulated during embryo development. However, the mechanisms that underlie these processes are not clear. Here, we built an in vitro model to mimic the cellular microenvironment of muscle by combining both mechanical stretch and geometrical control. We found that mechanical stretch was a key factor that determined the optimal geometry of myoblast C2C12 cells under stretch, whereas vascular endothelial cells and fibroblasts had no such dependency. We presented the first experimental evidence that can explain why myoblasts are destined to take the elongated geometry so as to survive and maintain parallel actin filaments along the stretching direction. The study is not only meaningful for the research on myogenesis but also has potential application in regenerative medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.