Evidence map›Paper›PMID 25146731›Full record

ArticleAnnals of neurology2014

Amyloid-β precursor protein synthesis inhibitors for Alzheimer's disease treatment.

Nigel H Greig, Kumar Sambamurti, Debomoy K Lahiri, Robert E Becker

Abstract readLetterComment
In one paragraph

Article in Annals of neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Nigel H GreigDrug Design and Development Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD.
Kumar Sambamurti
Debomoy K Lahiri
Robert E Becker

Funding

Design And Development Of Experimental Therapeutics ((Systemic & Neurodegenerative Disorders and Alzheimer's Disease)ZIAAG000311 · NIA · NATIONAL INSTITUTE ON AGING · PI GREIG, NIGEL H. · 2009 to 2025
$16.0M
Understanding the Neuroprotective Activities of PosiphenR21AG046200 · NIA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI SAMBAMURTI, KUMAR · 2013 to 2014
$411k
Intramural NIH HHS ZIA AG000311NIA NIH HHS R21 AG046200
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Gene Expression RegulationAmyloid beta-Protein PrecursorAnimalsFemaleHumansPlaque, AmyloidAmyloid beta-Protein Precursor

Identifiers

PMID25146731
PMCPMC5179032

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.