Evidence map›Paper›PMID 25146599›Full record

ArticleVirology2014

Increased virulence of rabbit haemorrhagic disease virus associated with genetic resistance in wild Australian rabbits (Oryctolagus cuniculus).

Peter Elsworth, Brian D Cooke, John Kovaliski, Ronald Sinclair, Edward C Holmes, Tanja Strive

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. The evolution of SARS-CoV-2.Nature reviews. Microbiology · 2023
    Review
  8. Article
  9. Review
  10. Immunity againstVaccines · 2021
    Review
  11. Evolutionary trajectory of fishEcology and evolution · 2020
    Article
  12. Article
  13. Contrasting evolution of virulence and replication rate in an emerging bacterial pathogen.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Peter ElsworthRobert Wicks Pest Animal Research Centre, Biosecurity Queensland, Department of Agriculture, Fisheries and Forestry, Toowoomba, Queensland, Australia; Invasive Animals Cooperative Research Centre, University of Canberra, Bruce, ACT, Canberra, Australia.
Brian D CookeInvasive Animals Cooperative Research Centre, University of Canberra, Bruce, ACT, Canberra, Australia; University of Canberra, Institute for Applied Ecology, ACT, Canberra, Australia.
John KovaliskiInvasive Animals Cooperative Research Centre, University of Canberra, Bruce, ACT, Canberra, Australia; Biosecurity South Australia, Adelaide, South Australia, Australia.
Ronald SinclairInvasive Animals Cooperative Research Centre, University of Canberra, Bruce, ACT, Canberra, Australia; Biosecurity South Australia, Adelaide, South Australia, Australia.
Edward C HolmesMarie Bashir Institute for Infectious Diseases & Biosecurity, Charles Perkins Centre, School of Biological Sciences and Sydney Medical School, The University of Sydney, Sydney, New South Wales 2006, Australia.
Tanja StriveInvasive Animals Cooperative Research Centre, University of Canberra, Bruce, ACT, Canberra, Australia; CSIRO Ecosystem Sciences, Canberra, ACT, Australia; CSIRO Biosecurity Flagship, Canberra, Australia. Electronic address: tanja.strive@csiro.au.
University of Canberra · AUCommonwealth Scientific and Industrial Research Organisation · AUThe University of Sydney · AU

Funding

Genomic analysis of the canonical case of virulence evolution: Myxomatosis in AuR01AI093804 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI READ, ANDREW F. · 2012 to 2016
$2.7M
NIAID NIH HHS R01 AI093804NIAID NIH HHS R01AI093804-01A1
6 · The paper itself

Abstract

The release of myxoma virus (MYXV) and Rabbit Haemorrhagic Disease Virus (RHDV) in Australia with the aim of controlling overabundant rabbits has provided a unique opportunity to study the initial spread and establishment of emerging pathogens, as well as their co-evolution with their mammalian hosts. In contrast to MYXV, which attenuated shortly after its introduction, rapid attenuation of RHDV has not been observed. By studying the change in virulence of recent field isolates at a single field site we show, for the first time, that RHDV virulence has increased through time, likely because of selection to overcome developing genetic resistance in Australian wild rabbits. High virulence also appears to be favoured as rabbit carcasses, rather than diseased animals, are the likely source of mechanical insect transmission. These findings not only help elucidate the co-evolutionary interaction between rabbits and RHDV, but reveal some of the key factors shaping virulence evolution.

Indexed as

AnimalsAustraliaCaliciviridae InfectionsHemorrhagic Disease Virus, RabbitPhylogenyRabbitsVirulenceAdaptive evolutionBiological controlCalicivirusEmerging diseaseGenetic resistanceRabbitTransmissionVirulence

Identifiers

PMID25146599
PMCPMC4598644
OpenAlexW2082979562

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.