ArticlePhysics in medicine and biology2014
Cherenkov excited phosphorescence-based pO2 estimation during multi-beam radiation therapy: phantom and simulation studies.
Article in Physics in medicine and biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Oxygels: Tunable Phosphorescent Hydrogels for Cherenkov-Excited Luminescence Imaging (CELI) of Oxygen.Advanced healthcare materials · 2026Article
- Cherenkov light emission in external beam radiation therapy of the larynx.Journal of biomedical optics · 2025Article
- Multiscale local sparsity and prior learning algorithm for Cherenkov-excited luminescence scanned tomography reconstruction.Applied optics · 2025Article
- Innovative approaches in precision radiation oncology: advanced imaging technologies and challenges which shape the future of radiation therapy.Frontiers in medicine · 2025Review
- Shining New Light on Biological Systems: Luminescent Transition Metal Complexes for Bioimaging and Biosensing Applications.Chemical reviews · 2024Review
- Optical Tissue Phantoms for Quantitative Evaluation of Surgical Imaging Devices.Advanced photonics research · 2023Article
- Cherenkov light emission in molecular radiation therapy of the thyroid and its application to dosimetry.Biomedical optics express · 2022Article
- High-Resolution pOInternational journal of radiation oncology, biology, physics · 2021Article
- Review of in vivo optical molecular imaging and sensing from x-ray excitation.Journal of biomedical optics · 2021Review
- Using Cherenkov imaging to monitor the match line between photon and electron radiation therapy fields on biological tissue phantoms.Journal of biomedical optics · 2020Article
- Implantable sensor for local Cherenkov-excited luminescence imaging of tumor pO2 during radiotherapy.Journal of biomedical optics · 2020Article
- Enhanced Cerenkov luminescence tomography analysis based on YBiomedical optics express · 2018Article
- Cherenkov excited short-wavelength infrared fluorescence imaging in vivo with external beam radiation.Journal of biomedical optics · 2018Article
- Optical and x-ray technology synergies enabling diagnostic and therapeutic applications in medicine.Journal of biomedical optics · 2018Review
- Multi-beam scan analysis with a clinical LINAC for high resolution Cherenkov-excited molecular luminescence imaging in tissue.Biomedical optics express · 2018Article
- Imaging of cortical oxygen tension and blood flow following targeted photothrombotic stroke.Neurophotonics · 2018Article
- Signal intensity analysis and optimization for in vivo imaging of Cherenkov and excited luminescence.Physics in medicine and biology · 2018Article
- Maps of in vivo oxygen pressure with submillimetre resolution and nanomolar sensitivity enabled by Cherenkov-excited luminescence scanned imaging.Nature biomedical engineering · 2018Article
- Kill-painting of hypoxic tumours in charged particle therapy.Scientific reports · 2015Article
- Review of biomedical Čerenkov luminescence imaging applications.Biomedical optics express · 2015Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Megavoltage radiation beams used in External Beam Radiotherapy (EBRT) generate Cherenkov light emission in tissues and equivalent phantoms. This optical emission was utilized to excite an oxygen-sensitive phosphorescent probe, PtG4, which has been developed specifically for NIR lifetime-based sensing of the partial pressure of oxygen (pO2). Phosphorescence emission, at different time points with respect to the excitation pulse, was acquired by an intensifier-gated CCD camera synchronized with radiation pulses delivered by a medical linear accelerator. The pO2 distribution was tomographically recovered in a tissue-equivalent phantom during EBRT with multiple beams targeted from different angles at a tumor-like anomaly. The reconstructions were tested in two different phantoms that have fully oxygenated background, to compare a fully oxygenated and a fully deoxygenated inclusion. To simulate a realistic situation of EBRT, where the size and location of the tumor is well known, spatial information of a prescribed region was utilized in the recovery estimation. The phantom results show that region-averaged pO2 values were recovered successfully, differentiating aerated and deoxygenated inclusions. Finally, a simulation study was performed showing that pO2 in human brain tumors can be measured to within 15 mmHg for edge depths less than 10-20 mm using the Cherenkov Excited Phosphorescence Oxygen imaging (CEPhOx) method and PtG4 as a probe. This technique could allow non-invasive monitoring of pO2 in tumors during the normal process of EBRT, where beams are generally delivered from multiple angles or arcs during each treatment fraction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.