SynthesisScientific reports2014
Relationship between melatonin receptor 1B and insulin receptor substrate 1 polymorphisms with gestational diabetes mellitus: a systematic review and meta-analysis.
Synthesis in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Pooled it
- A functional polymorphism rs10830963 in melatonin receptor 1B associated with the risk of gestational diabetes mellitus.Bioscience reports · 2019Pooled it
- Genetic variants associated with gestational diabetes mellitus: a meta-analysis and subgroup analysis.Scientific reports · 2016Pooled it
- Melatonin in Pregnancy-Related Disorders: A Review of Protective Mechanisms and Therapeutic Potential.Reproductive sciences (Thousand Oaks, Calif.) · 2026Review
- Genetic and epigenetic alterations associated with gestational diabetes mellitus and adverse neonatal outcomes.World journal of clinical pediatrics · 2025Review
- Association between insulin receptor substrate 1 gene polymorphism rs1801278 and gestational diabetes mellitus: an updated meta- analysis.Diabetology & metabolic syndrome · 2024Article
- The melatonin receptor 1B gene links circadian rhythms and type 2 diabetes mellitus: an evolutionary story.Annals of medicine · 2023Review
- Genetic and Epigenetic Factors in Gestational Diabetes Mellitus Pathology.International journal of molecular sciences · 2023Review
- The Role of Melatonin in Pregnancy and the Health Benefits for the Newborn.Biomedicines · 2022Review
- Association of surfactant protein D gene polymorphism with susceptibility to gestational diabetes mellitus: a case-control study.BMC pregnancy and childbirth · 2022Article
- An early prediction model for gestational diabetes mellitus based on genetic variants and clinical characteristics in China.Diabetology & metabolic syndrome · 2022Article
- Urinary Angiotensinogen-Melatonin Ratio in Gestational Diabetes and Preeclampsia.Frontiers in molecular biosciences · 2022Article
- Pathophysiological Role of Genetic Factors Associated With Gestational Diabetes Mellitus.Frontiers in physiology · 2022Review
- Melatonin Receptor 1B Genetic Variants on Susceptibility to Gestational Diabetes Mellitus: A Hospital-Based Case-Control Study in Wuhan, Central China.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Impact of Early Nutrition, Physical Activity and Sleep on the Fetal Programming of Disease in the Pregnancy: A Narrative Review.Nutrients · 2020Review
- Genetics and Epigenetics: New Insight on Gestational Diabetes Mellitus.Frontiers in endocrinology · 2020Review
- Novel Genetic Variants ofFrontiers in endocrinology · 2020Article
- Whether the risk of gestational diabetes mellitus is affected byDiabetology & metabolic syndrome · 2020Article
- Association ofJournal of diabetes and metabolic disorders · 2018Article
- A Review of Data of Findings on Night Shift Work and the Development of DM and CVD Events: a Synthesis of the Proposed Molecular Mechanisms.Current diabetes reports · 2018Review
Corrections and comments
- Retraction · 2025-02-25Author Unresponsive · Euphemisms for Plagiarism · Investigation by Journal/Publisher · Plagiarism of/in Article ·
- Retracted
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies have investigated the relationship between genetic variants and risk of gestational diabetes mellitus (GDM). However, the results remain inconclusive. The aim of this study was to investigate the association of rs10830963 and rs1387153 variants in melatonin receptor 1B (MTNR1B) and rs1801278 variant in insulin receptor substrate 1 (IRS1) with GDM susceptibility. Electronic database of PubMed, Medline, Embase, and CNKI (China National Knowledge Infrastructure) were searched for relevant studies between 2005 and 2014. The odds ratio (OR) with its 95% confidence interval (CI) were employed to estimate the association. Total ten case-control studies, including 3428 GDM cases and 4637 healthy controls, met the inclusion criteria. Our results showed a significant association between the three genetic variants and GDM risk, rs10830963 with a P-value less than 0.0001, rs1387153 with a P-value of 0.0002, and rs1801278 with a P-value of 0.001. Furthermore, all the genetic models in these three polymorphisms were associated with increased risks of GDM as well (P< = 0.009). In conclusion, our study found that the genetic polymorphisms rs10830963 and rs1387153 in MTNR1B and rs1801278 in IRS1 were associated with an increased risk of developing GDM. However, further studies with gene-gene and gene-environmental interactions should be considered.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.