ArticleThe European journal of neuroscience2014
Frequency matters: beta-band subthalamic nucleus deep-brain stimulation induces Parkinsonian-like blink abnormalities in normal rats.
Article in The European journal of neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Transcranial alternating current stimulation can modulate the blink reflex excitability. Effects of a 10- and 20-Hz tACS session on the blink reflex recovery cycle in healthy subjects.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Closed-loop modulation of model parkinsonian beta oscillations based on CAR-fuzzy control algorithm.Cognitive neurodynamics · 2023Article
- Subthalamic low-frequency oscillations predict vulnerability to cocaine addiction.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Delta oscillations are a robust biomarker of dopamine depletion severity and motor dysfunction in awake mice.Journal of neurophysiology · 2020Article
- Error Analysis and Some Suggestions on Animal Stereotactic Experiment from Inaccuracy of Rhesus Macaques Atlas.Chinese medical journal · 2016Article
- Common therapeutic mechanisms of pallidal deep brain stimulation for hypo- and hyperkinetic movement disorders.Journal of neurophysiology · 2015Review
- Translational neurophysiology of Parkinson's disease: can't blink on an eye blink.Journal of neurophysiology · 2015Article
- Effects of subthalamic deep brain stimulation on blink abnormalities of 6-OHDA lesioned rats.Journal of neurophysiology · 2015Article
- Movement-related discharge in the macaque globus pallidus during high-frequency stimulation of the subthalamic nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The synchronized beta-band oscillations in the basal ganglia-cortical networks in Parkinson's disease (PD) may be responsible for PD motor symptoms or an epiphenomenon of dopamine loss. We investigated the causal role of beta-band activity in PD motor symptoms by testing the effects of beta-frequency subthalamic nucleus deep-brain stimulation (STN DBS) on the blink reflex excitability, amplitude, and plasticity in normal rats. Delivering 16 Hz STN DBS produced the same increase in blink reflex excitability and impairment in blink reflex plasticity in normal rats as occurs in rats with 6-hydroxydopamine lesions and patients with PD. These deficits were not an artifact of STN DBS because, when these normal rats received 130 Hz STN DBS, their blink characteristics were the same as without STN DBS. To demonstrate that the blink reflex disturbances with 16 Hz STN DBS were frequency specific, we tested the same rats with 7 Hz STN DBS, a theta-band frequency typical of dystonia. In contrast to beta stimulation, 7 Hz STN DBS exaggerated the blink reflex plasticity as occurs in focal dystonia. Thus, without destroying dopamine neurons or blocking dopamine receptors, frequency-specific STN DBS can be used to create PD-like or dystonic-like symptoms in a normal rat.
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