ArticleScientific reports2014
The construction of hierarchical structure on Ti substrate with superior osteogenic activity and intrinsic antibacterial capability.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Hierarchical Micro-Nano Surface Roughness Wax-Impregnated Cotton Fabrics Platform for Cell-Based Diagnostics.ACS omega · 2025Article
- Piranha-etched titanium nanostructure reduces biofilm formation in vitro.Clinical oral investigations · 2023Article
- Antimicrobial potential and osteoblastic cell growth on electrochemically modified titanium surfaces with nanotubes and selenium or silver incorporation.Scientific reports · 2022Article
- Antibacterial Activity of Silver and Gold Particles Formed on Titania Thin Films.Nanomaterials (Basel, Switzerland) · 2022Article
- Effect of a Nanostructured Titanium Surface on Gingival Cell Adhesion, Viability and Properties againstMaterials (Basel, Switzerland) · 2021Article
- Ultra-Short Laser Surface Properties Optimization of Biocompatibility Characteristics of 3D Poly-ε-Caprolactone and Hydroxyapatite Composite Scaffolds.Materials (Basel, Switzerland) · 2021Article
- High-throughput screening and rational design of biofunctionalized surfaces with optimized biocompatibility and antimicrobial activity.Nature communications · 2021Article
- Additive manufacturing of Ti6Al4V alloy via electron beam melting for the development of implants for the biomedical industry.Heliyon · 2021Review
- Titanium and Protein Adsorption: An Overview of Mechanisms and Effects of Surface Features.Materials (Basel, Switzerland) · 2021Review
- Topography: A Biophysical Approach to Direct the Fate of Mesenchymal Stem Cells in Tissue Engineering Applications.Nanomaterials (Basel, Switzerland) · 2020Review
- Vancomycin-loaded titanium coatings with an interconnected micro-patterned structure for prophylaxis of infections: anRSC advances · 2018Article
- Micro/nano hierarchical structured titanium treated by NH4OH/H2O2 for enhancing cell response.PloS one · 2018Article
- Nanoscale Topography on Black Titanium Imparts Multi-biofunctional Properties for Orthopedic Applications.Scientific reports · 2017Article
- Silver-nanoparticles-modified biomaterial surface resistant to staphylococcus: new insight into the antimicrobial action of silver.Scientific reports · 2016Article
- Surface thermal oxidation on titanium implants to enhance osteogenic activity and in vivo osseointegration.Scientific reports · 2016Article
- Multifunctional coatings to simultaneously promote osseointegration and prevent infection of orthopaedic implants.Biomaterials · 2016Review
- Facile Synthesis of Photofunctional Nanolayer Coatings on Titanium Substrates.BioMed research international · 2016Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The deficient osseointegration and implant-associated infections are pivotal issues for the long-term clinical success of endosteal Ti implants, while development of functional surfaces that can simultaneously overcome these problems remains highly challenging. This study aimed to fabricate sophisticated Ti implant surface with both osteogenic inducing activity and inherent antibacterial ability simply via tailoring surface topographical features. Micro/submciro/nano-scale structure was constructed on Ti by three cumulative subtractive methods, including sequentially conducted sandblasting as well as primary and secondary acid etching treatment. Topographical features of this hierarchical structure can be well tuned by the time of the secondary acid treatment. Ti substrate with mere micro/submicro-scale structure (MS0-Ti) served as a control to examine the influence of hierarchical structures on surface properties and biological activities. Surface analysis indicated that all hierarchically structured surfaces possessed exactly the same surface chemistry as that of MS0-Ti, and all of them showed super-amphiphilicity, high surface free energy, and high protein adsorption capability. Biological evaluations revealed surprisingly antibacterial ability and excellent osteogenic activity for samples with optimized hierarchical structure (MS30-Ti) when compared with MS0-Ti. Consequently, for the first time, a hierarchically structured Ti surface with topography-induced inherent antibacterial capability and excellent osteogenic activity was constructed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.