ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2014
A web tool for age-period-cohort analysis of cancer incidence and mortality rates.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 505 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
505 citing papers in PubMed.
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- Comparative analysis of female breast cancer burden in China along the global sociodemographic gradient: risk attribution, decomposition, and age-period-cohort evidence from GBD 2021.Clinics (Sao Paulo, Brazil) · 2026Article
- Analgesic Prescribing Trends of Opioids, Nonsteroidal Anti-Inflammatory Drugs, and Paracetamol in Taiwan (2001-2020): Age-Period-Cohort Cross-Sectional Study.JMIR public health and surveillance · 2026Article
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- Age period cohort trends in alcohol treatment episodes across Australia from 2003 to 2022.Addiction (Abingdon, England) · 2026Article
- Incidence patterns and trends of chordoma in the United States: a population-based analysis of over 6,000 cases.Journal of bone oncology · 2026Article
- Global, Regional, and National Burden of Malaria and Dengue from 1992 to 2021, with Projections to 2036: An Age-Period-Cohort Analysis.Tropical medicine and infectious disease · 2026Article
- Prevalence and associated factors of metabolic dysfunction-associated steatotic liver disease in Taiwan, 2001-2021.Hepatology international · 2026Article
- Diverging trends in motor neuron disease burden in China: an ageing-driven increase despite declining age-standardised rates - a GBD 2021 analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Global, Regional, and National Burden of Infertility Attributable to Sexually Transmitted Infections From 1990 to 2021, With Projections to 2050.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2026Article
- Trends in Female Breast Cancer Incidence among Japanese, Korean, and US Populations: An Age-Period-Cohort Analysis.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026Article
- Trends in malignant mesothelioma incidence in Spain, 1999-2023: a joinpoint and age-period-cohort analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Low Back Pain in Chinese Adults Aged 45 Years and Older: Trends, Drivers, and Projections, 1990-2040.Healthcare (Basel, Switzerland) · 2026Article
- Evolving Patterns of Oral Disease Burden in China, 1990-2021: Evidence From the Global Burden of Disease Study.International dental journal · 2026Article
- Global burden and forecast of acute viral hepatitis B among women of childbearing age: a systematic analysis of the global burden of disease study 2021.BMC infectious diseases · 2026Article
- Age-Period-Cohort Analysis of Suicide Mortality in Japan: A 40-Year Nationwide and Prefectural-Level Study.JMA journal · 2026Article
- Temporal trends of clinicopathological features, therapeutic modalities, and survival outcomes in pseudo-age-related colorectal cancer.Scientific reports · 2026Article
445 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
backgroundAge-period-cohort (APC) analysis can inform registry-based studies of cancer incidence and mortality, but concerns about statistical identifiability and interpretability, as well as the learning curves of statistical software packages, have limited its uptake.
methodsWe implemented a panel of easy-to-interpret estimable APC functions and corresponding Wald tests in R code that can be accessed through a user-friendly Web tool.
resultsInput data for the Web tool consist of age-specific numbers of events and person-years over time, in the form of a rate matrix of paired columns. Output functions include model-based estimators of cross-sectional and longitudinal age-specific rates, period and cohort rate ratios that incorporate the overall annual percentage change (net drift), and estimators of the age-specific annual percentage change (local drifts). The Web tool includes built-in examples for teaching and demonstration. User data can be input from a Microsoft Excel worksheet or by uploading a comma-separated-value file. Model outputs can be saved in a variety of formats, including R and Excel.
conclusionsAPC methodology can now be carried out through a freely available user-friendly Web tool. The tool can be accessed at http://analysistools.nci.nih.gov/apc/. IMPACT: The Web tool can help cancer surveillance researchers make important discoveries about emerging cancer trends and patterns.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.