Evidence map›Paper›PMID 25146026›Full record

ArticleJournal of endodontics2014

Capping a pulpotomy with calcium aluminosilicate cement: comparison to mineral trioxide aggregates.

Phillip R Kramer, Karl F Woodmansey, Robert White, Carolyn M Primus, Lynne A Opperman

Open access · greenAbstract readComparative Study
In one paragraph

Article in Journal of endodontics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Review
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  6. Review
  7. Frontiers in bioengineering and biotechnology · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Phillip R KramerDepartment of Biomedical Sciences, Texas A and M Baylor College of Dentistry, Dallas, Texas. Electronic address: pkramer@bcd.tamhsc.edu.
Karl F WoodmanseyDepartment of Endodontics, Department of Biomedical Sciences, Texas A and M Baylor College of Dentistry, Dallas, Texas.
Robert WhiteDepartment of Endodontics, Department of Biomedical Sciences, Texas A and M Baylor College of Dentistry, Dallas, Texas.
Carolyn M PrimusPrimus Consulting, Bradenton, Florida.
Lynne A OppermanDepartment of Biomedical Sciences, Texas A and M Baylor College of Dentistry, Dallas, Texas.
Baylor University · USPrimus Consulting (United States) · US

Funding

Quick-Set Material-Phase IIR44DE020204 · NIDCR · PRIMUS CONSULTING · PI PRIMUS, CAROLYN MARGARET · 2012 to 2014
$1.3M
Quick-Set Endodontic MaterialR43DE020204 · NIDCR · PRIMUS CONSULTING · PI PRIMUS, CAROLYN MARGARET · 2010 to 2010
$100k
NIDCR NIH HHS DE020204NIDCR NIH HHS R43 DE020204NIDCR NIH HHS R44 DE020204
6 · The paper itself

Abstract

introductionCalcium aluminate cements have shown little affinity for bacterial growth, low toxicity, and immunogenicity when used as a restoration material, but calcium aluminate cements have not been tested in vivo in pulpotomy procedures.

methodsTo address this question, a calcium aluminosilicate cement (Quick-Set) was tested along with 2 mineral trioxide aggregates, ProRoot MTA and MTA Plus. These cements were used as a capping agent after pulpotomy. Control rats had no pulpotomy, or the pulpotomy was not capped. Proinflammatory cytokines interleukin (IL)-1β and IL-1α were measured, and histology was performed at 30 and 60 days after capping. The nociceptive response was determined by measuring the lengthening of the rat's meal duration.

resultsand

conclusionsIL-1β and IL-1α concentrations were reduced in the capped teeth, but no differences were observed among the 3 cements. Dentinal bridging could be detected at both 30 and 60 days with each of the 3 cements, and the pulps were still vital 60 days after capping. Meal duration significantly shortened after placement of the 3 different cements, indicating a nociceptive response, but there were no differences among the materials. Calcium aluminosilicate cement had similar properties to mineral trioxide aggregates and is a viable option for pulpotomy procedures.

Indexed as

Aluminum CompoundsAluminum SilicatesAnimalsBacterial LoadCalcium CompoundsClayDental CementsDental PulpDentin, SecondaryDrug CombinationsEatingInflammation MediatorsInterleukin-1alphaInterleukin-1betaMaterials TestingNociceptionAluminum CompoundsAluminum SilicatesCalcium CompoundsClayDental CementsDrug CombinationsInflammation MediatorsInterleukin-1alphaInterleukin-1betamineral trioxide aggregateOxidesPulp Capping and Pulpectomy AgentsQuick-SetSilicatesCalcium aluminate/aluminosilicate cementcalcium silicateendodonticmineral trioxide aggregatepaintricalcium silicate

Identifiers

PMID25146026
PMCPMC4143630
OpenAlexW2072577640

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.