ArticleJournal of visualized experiments : JoVE2014
Technique of subnormothermic ex vivo liver perfusion for the storage, assessment, and repair of marginal liver grafts.
Article in Journal of visualized experiments : JoVE, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Cyclosporine A Does Not Mitigate Liver Ischemia/Reperfusion Injury in an Ex Vivo Porcine Model of Donation After Circulatory Death.Annals of transplantation · 2024Article
- Comprehensive review of the application of MP and the potential for graft modification.Frontiers in transplantation · 2023Review
- Article
- Subnormothermic Ex Vivo Lung Perfusion Temperature Improves Graft Preservation in Lung Transplantation.Cells · 2021Article
- Subnormothermic ex vivo lung perfusion attenuates ischemia reperfusion injury from donation after circulatory death donors.PloS one · 2021Article
- Establishing In Situ Closed Circuit Perfusion of Lower Abdominal Organs and Hind Limbs in Mice.Journal of visualized experiments : JoVE · 2020Article
- Initial perfusate purification during subnormothermic machine perfusion for porcine liver donated after cardiac death.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2020Article
- Machine Perfusion of Extended Criteria Donor Organs: Immunological Aspects.Frontiers in immunology · 2020Review
- Optimizing organs for transplantation; advancements in perfusion and preservation methods.Transplantation reviews (Orlando, Fla.) · 2020Review
- De-epithelialization of porcine tracheal allografts as an approach for tracheal tissue engineering.Scientific reports · 2019Article
- Cold flush after dynamic liver preservation protects against ischemic changes upon reperfusion - an experimental study.Transplant international : official journal of the European Society for Organ Transplantation · 2019Article
- Impact of Machine Perfusion on Biliary Complications after Liver Transplantation.International journal of molecular sciences · 2018Review
- Pushing the Limits: Machine Preservation of the Liver as a Tool to Recondition High-Risk Grafts.Current transplantation reports · 2018Review
- Graft Reconditioning before Liver Transplantation.Visceral medicine · 2016Article
- Role of NK, NKT cells and macrophages in liver transplantation.World journal of gastroenterology · 2016Review
- Donor Hepatic Steatosis Induce Exacerbated Ischemia-Reperfusion Injury Through Activation of Innate Immune Response Molecular Pathways.Transplantation · 2015Article
- Declining liver graft quality threatens the future of liver transplantation in the United States.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2015Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The success of liver transplantation has resulted in a dramatic organ shortage. In most transplant regions 20-30% of patients on the waiting list for liver transplantation die without receiving an organ transplant or are delisted for disease progression. One strategy to increase the donor pool is the utilization of marginal grafts, such as fatty livers, grafts from older donors, or donation after cardiac death (DCD). The current preservation technique of cold static storage is only poorly tolerated by marginal livers resulting in significant organ damage. In addition, cold static organ storage does not allow graft assessment or repair prior to transplantation. These shortcomings of cold static preservation have triggered an interest in warm perfused organ preservation to reduce cold ischemic injury, assess liver grafts during preservation, and explore the opportunity to repair marginal livers prior to transplantation. The optimal pressure and flow conditions, perfusion temperature, composition of the perfusion solution and the need for an oxygen carrier has been controversial in the past. In spite of promising results in several animal studies, the complexity and the costs have prevented a broader clinical application so far. Recently, with enhanced technology and a better understanding of liver physiology during ex vivo perfusion the outcome of warm liver perfusion has improved and consistently good results can be achieved. This paper will provide information about liver retrieval, storage techniques, and isolated liver perfusion in pigs. We will illustrate a) the requirements to ensure sufficient oxygen supply to the organ, b) technical considerations about the perfusion machine and the perfusion solution, and c) biochemical aspects of isolated organs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.