ArticleJournal of visualized experiments : JoVE2014
Assessment of murine exercise endurance without the use of a shock grid: an alternative to forced exercise.
Article in Journal of visualized experiments : JoVE, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed.
- Immuno-oncological effects of aerobic exercise combined with anti-PD-L1 antibody blockade in a murine breast cancer model.Frontiers in oncology · 2026Article
- Topical Application of Jojoba Oil Suppresses Exercise-Induced Inflammatory Gene Expression in Mouse Skeletal Muscle.Biomolecules · 2025Article
- Effects of defined voluntary running distances coupled with high-fat diet consumption on the skeletal muscle transcriptome of male mice.Physiological reports · 2025Article
- Effect of acute high-intensity interval exercise on a mouse model of doxorubicin-induced cardiotoxicity: a pilot study.BMC sports science, medicine & rehabilitation · 2024Article
- A Formalized Method to Acclimate Dogs to Voluntary Treadmill Locomotion at Various Speeds and Inclines.Animals : an open access journal from MDPI · 2022Article
- A review of physical activity in pancreatic ductal adenocarcinoma: Epidemiology, intervention, animal models, and clinical trials.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2022Review
- Physical exercise shapes the mouse brain epigenome.Molecular metabolism · 2021Article
- Functional significance of gain-of-function H19 lncRNA in skeletal muscle differentiation and anti-obesity effects.Genome medicine · 2021Article
- Comparison of intrinsic exercise capacity and response to acute exercise in ICR (Institute of Cancer Research) mice derived from three different lineages.Laboratory animal research · 2021Article
- Monitoring daytime differences in moderate intensity exercise capacity using treadmill test and muscle dissection.STAR protocols · 2021Article
- Resistance and Endurance Exercise Training Induce Differential Changes in Gut Microbiota Composition in Murine Models.Frontiers in physiology · 2021Article
- The lncRNA H19 alleviates muscular dystrophy by stabilizing dystrophin.Nature cell biology · 2020Article
- Is physical performance (in mice) increased by Veillonella atypica or decreased by Lactobacillus bulgaricus?Journal of sport and health science · 2020Article
- Adipocyte-specific gp130 signalling mediates exercise-induced weight reduction.International journal of obesity (2005) · 2020Article
- Mouse Fitness as Determined Through Treadmill Running and Walking.Methods in molecular biology (Clifton, N.J.) · 2020Article
- CITED2 mediates the cross-talk between mechanical loading and IL-4 to promote chondroprotection.Annals of the New York Academy of Sciences · 2019Article
- Short Session High Intensity Interval Training and Treadmill Assessment in Aged Mice.Journal of visualized experiments : JoVE · 2019Article
- Ethical consideration and feasibility demonstration of high-intensity interval training without the use of electrical shocks in mice with and without doxorubicin exposition.American journal of cancer research · 2019Article
- Continuing Challenges in Advancing Preclinical Science in Skeletal Cell-Based Therapies and Tissue Regeneration.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018Article
- The Effects of Thiamine Tetrahydrofurfuryl Disulfide on Physiological Adaption and Exercise Performance Improvement.Nutrients · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Using laboratory mouse models, the molecular pathways responsible for the metabolic benefits of endurance exercise are beginning to be defined. The most common method for assessing exercise endurance in mice utilizes forced running on a motorized treadmill equipped with a shock grid. Animals who quit running are pushed by the moving treadmill belt onto a grid that delivers an electric foot shock; to escape the negative stimulus, the mice return to running on the belt. However, avoidance behavior and psychological stress due to use of a shock apparatus can interfere with quantitation of running endurance, as well as confound measurements of postexercise serum hormone and cytokine levels. Here, we demonstrate and validate a refined method to measure running endurance in naïve C57BL/6 laboratory mice on a motorized treadmill without utilizing a shock grid. When mice are preacclimated to the treadmill, they run voluntarily with gait speeds specific to each mouse. Use of the shock grid is replaced by gentle encouragement by a human operator using a tongue depressor, coupled with sensitivity to the voluntary willingness to run on the part of the mouse. Clear endpoints for quantifying running time-to-exhaustion for each mouse are defined and reflected in behavioral signs of exhaustion such as splayed posture and labored breathing. This method is a humane refinement which also decreases the confounding effects of stress on experimental parameters.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.