ArticleJournal of tropical pediatrics2014
Increased morbidity in early childhood among HIV-exposed uninfected children in Uganda is associated with breastfeeding duration.
Article in Journal of tropical pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00948896 (A Randomized Controlled Trial of Monthly Dihydroartemisinin-piperaquine Versus Monthly Sulfadoxine-pyrimethamine Versus Daily Trimethoprim-sulfamethoxazole Versus No Therapy for the Prevention of Malaria), which is not on this map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Controlled Trial of Monthly Dihydroartemisinin-piperaquine Versus Monthly Sulfadoxine-pyrimethamine Versus Daily Trimethoprim-sulfamethoxazole Versus No Therapy for the Prevention of Malaria
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A Meta-analysis Assessing Diarrhea and Pneumonia in HIV-Exposed Uninfected Compared With HIV-Unexposed Uninfected Infants and Children.Journal of acquired immune deficiency syndromes (1999) · 2019Pooled it
- Mortality risk and associated factors in HIV-exposed, uninfected children.Tropical medicine & international health : TM & IH · 2016Pooled it
- What do we know about children living with HIV-infected or AIDS-ill adults in Sub-Saharan Africa? A systematic review of the literature.AIDS care · 2016Pooled it
- Neruodevelopmental Outcomes in Preschool Children Living With HIV-1 Subtypes A and D in Uganda.The Pediatric infectious disease journal · 2018Trial
- Prevention of HIV-1 Transmission Through Breastfeeding: Efficacy and Safety of Maternal Antiretroviral Therapy Versus Infant Nevirapine Prophylaxis for Duration of Breastfeeding in HIV-1-Infected Women With High CD4 Cell Count (IMPAACT PROMISE): A Randomized, Open-Label, Clinical Trial.Journal of acquired immune deficiency syndromes (1999) · 2018Trial
- Complementary Feeding and Diarrhea and Respiratory Infection Among HIV-Exposed Tanzanian Infants.Journal of acquired immune deficiency syndromes (1999) · 2017Trial
- Malaria illness mediated by anaemia lessens cognitive development in younger Ugandan children.Malaria journal · 2016Trial
- Effect of Caregiver Training on the Neurodevelopment of HIV-Exposed Uninfected Children and Caregiver Mental Health: A Ugandan Cluster-Randomized Controlled Trial.Journal of developmental and behavioral pediatrics : JDBPTrial
- Infectious morbidity among children HIV-exposed uninfected in South Africa.AIDS (London, England) · 2026Article
- Review
- Impact of HIV exposure without infection on hospital course and mortality among young children in sub-Saharan Africa: a multi-site cohort study.BMC medicine · 2024Article
- Prevalence, patterns, and determinants of breastfeeding cessation among mothers of children under 24 months in Uganda.BMC public health · 2024Article
- Review
- Morbidity and Mortality of HIV-Exposed Uninfected Infants in a Tertiary Referral Facility in Yaoundé, Cameroon.International journal of MCH and AIDS · 2023Article
- Growth patterns and clinical outcomes in association with breastfeeding duration in HIV exposed and unexposed infants: a cohort study in KwaZulu Natal, South Africa.BMC pediatrics · 2021Article
- Mortality among children under five years admitted for routine care of severe acute malnutrition: a prospective cohort study from Kampala, Uganda.BMC pediatrics · 2020Article
- Examining the relationship between diarrhea and linear growth in Kenyan HIV-exposed, uninfected infants.PloS one · 2020Article
- Growth of HIV-uninfected children born to HIV-infected mothers in Guangdong, China: an 18-month longitudinal follow-up study.BMC pediatrics · 2019Article
- Impact of maternal HIV exposure, feeding status, and microbiome on infant cellular immunity.Journal of leukocyte biology · 2019Review
- Contribution of Maternal Antiretroviral Therapy and Breastfeeding to 24-Month Survival in Human Immunodeficiency Virus-Exposed Uninfected Children: An Individual Pooled Analysis of African and Asian Studies.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Human immunodeficiency virus (HIV)-exposed uninfected children (HEU) have an increased risk of morbidity and mortality compared with HIV-unexposed uninfected children (HUU); however, prior studies have not fully accounted for the role of both breastfeeding and age on this association. In this cohort of HEU and HUU in Uganda, non-breastfeeding HEU, from 6-11 months compared with non-breastfeeding HUU had a higher risk of hospitalizations [relative risk (RR): 10.1, 95% confidence interval (CI): 3.70-27.6], severe febrile illness (RR: 3.84, 95% CI: 2.06-7.17), severe diarrhea (RR: 6.37, 95% CI: 2.32-17.4) and severe malnutrition (RR: 18.4, 95% CI: 4.68-72.0). There were no differences between morbidity outcomes between breastfeeding HEU and HUU children, aged 6-11 months. In the 12-24 month age group, the only difference in morbidity outcomes among non-breast feeding children was an increased risk of severe malnutrition for HEU. These data suggest that the increased risk of morbidity among HEU aged 6-11 years is partially explained by early cessation of breastfeeding.
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