ArticleDiabetologia2014
Global DNA methylation levels in human adipose tissue are related to fat distribution and glucose homeostasis.
Article in Diabetologia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 59 citations in OpenAlex.
- Blood and adipose tissue DNA methylation in adults born preterm with a very low birth weight - a sibling comparison study.Epigenomics · 2026Article
- Global mapping of RNA NBiomarker research · 2025Article
- Regulators of RNA mFrontiers in endocrinology · 2025Article
- Article
- Long-term variability in physiological measures in relation to mortality and epigenetic aging: prospective studies in the USA and China.BMC medicine · 2023Article
- Effects of hydroxyapatite-coated nonwoven polyethylene/polypropylene fabric on non-mesodermal lineage-specific differentiation of human adipose-derived stem cells.BMC research notes · 2020Article
- Methylome-wide association study of central adiposity implicates genes involved in immune and endocrine systems.Epigenomics · 2020Article
- Ethnic and Adipose Depot Specific Associations Between DNA Methylation and Metabolic Risk.Frontiers in genetics · 2020Article
- Synergistic Effects of Hyperandrogenemia and Obesogenic Western-style Diet on Transcription and DNA Methylation in Visceral Adipose Tissue of Nonhuman Primates.Scientific reports · 2019Article
- Comparison of visceral adipose tissue DNA methylation and gene expression profiles in female adolescents with obesity.Diabetology & metabolic syndrome · 2019Article
- CD4Obesity (Silver Spring, Md.) · 2018Article
- Differentiation of human adipose-derived stem cells into cardiomyocyte-like cells in fibrin scaffold by a histone deacetylase inhibitor.Biomedical engineering online · 2017Article
- IRS1 DNA promoter methylation and expression in human adipose tissue are related to fat distribution and metabolic traits.Scientific reports · 2017Article
- Genome-wide DNA promoter methylation and transcriptome analysis in human adipose tissue unravels novel candidate genes for obesity.Molecular metabolism · 2017Article
- Altered intragenic DNA methylation of HOOK2 gene in adipose tissue from individuals with obesity and type 2 diabetes.PloS one · 2017Article
- DNA methylation and gene expression patterns in adipose tissue differ significantly within young adult monozygotic BMI-discordant twin pairs.International journal of obesity (2005) · 2016Article
- Disagreement between two common biomarkers of global DNA methylation.Clinical epigenetics · 2016Article
- Subsets of Visceral Adipose Tissue Nuclei with Distinct Levels of 5-Hydroxymethylcytosine.PloS one · 2016Article
- An analysis of DNA methylation in human adipose tissue reveals differential modification of obesity genes before and after gastric bypass and weight loss.Genome biology · 2015Article
- The potential use of DNA methylation biomarkers to identify risk and progression of type 2 diabetes.Frontiers in endocrinology · 2015Review
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisEpigenetic alterations may influence the metabolic pathways involved in human obesity. We hypothesised that global DNA methylation levels in adipose tissue might be associated with obesity and related phenotypes.
methodsWe measured global DNA methylation levels in paired samples of subcutaneous adipose tissue (SAT) and omental visceral adipose tissue (OVAT) from 51 individuals, and in leucocytes from 559 Sorbs, a population from Germany, using LUminometric Methylation Assay (LUMA). To further investigate the underlying mechanisms of the observed associations, we measured global methylation levels in 3T3-L1 adipocytes exposed to glucose, insulin and lipids.
resultsGlobal methylation levels (±SD) were significantly higher in OVAT (74.27% ± 2.2%) compared with SAT (71.97% ± 2.4%; paired t test, p < 1 × 10(-9)). Furthermore, global methylation levels in SAT were positive correlates of measures of fat distribution (waist measurement, WHR) and glucose homeostasis (HbA1c) (all p < 0.015 after accounting for multiple testing and covariates). Global methylation levels in the German Sorb cohort were associated with glucose homeostasis, but this association did not withstand adjustment for covariates. Exposure of 3T3-L1 adipocytes to insulin, palmitate and glucose decreased global methylation levels 1 h after treatment relative to controls. CONCLUSIONS/
interpretationOur data suggest that the variability in global methylation in adipose tissue might be related to alterations in glucose metabolism.
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