SynthesisDiabetologia2014
Does genetic heterogeneity account for the divergent risk of type 2 diabetes in South Asian and white European populations?
Synthesis in Diabetologia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Single nucleotide polymorphisms (SNPs) that are associated with obesity and type 2 diabetes among Asians: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Genetic Screening of Genome-Wide Association Studies-Derived Risk Loci for Type 2 Diabetes Mellitus:Sultan Qaboos University medical journal · 2025Article
- Extending precision medicine tools to populations at high risk of type 2 diabetes.PLoS medicine · 2022Article
- Type 2 diabetes risks and determinants in second-generation migrants and mixed ethnicity people of South Asian and African Caribbean descent in the UK.Diabetologia · 2022Article
- Article
- Subgroup Variation and Neighborhood Social Gradients-an Analysis of Hypertension and Diabetes Among Asian Patients (New York City, 2014-2017).Journal of racial and ethnic health disparities · 2021Article
- Association of the JAZF1 Variant in Adults With a Parental History of Type 2 Diabetes Mellitus In Pakistan.Cureus · 2020Article
- Prevalence, incidence and predictors of cardiovascular risk factors: longitudinal data from rural and urban South India and comparison with global data.BMJ open diabetes research & care · 2020Article
- Review
- Obesity in International Migrant Populations.Current obesity reports · 2017Review
- Body composition and susceptibility to type 2 diabetes: an evolutionary perspective.European journal of clinical nutrition · 2017Review
- Association of recently identified type 2 diabetes gene variants with Gestational Diabetes in Asian Indian population.Molecular genetics and genomics : MGG · 2017Article
- Empirical evaluation of the Q-Genie tool: a protocol for assessment of effectiveness.BMJ open · 2016Article
- The Elevated Susceptibility to Diabetes in India: An Evolutionary Perspective.Frontiers in public health · 2016Review
- Ethnic differences in prediabetes and diabetes in the Suriname Health Study.BMJ open diabetes research & care · 2016Article
- Assessing the quality of published genetic association studies in meta-analyses: the quality of genetic studies (Q-Genie) tool.BMC genetics · 2015Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisSouth Asians are up to four times more likely to develop type 2 diabetes than white Europeans. It is postulated that the higher prevalence results from greater genetic risk. To evaluate this hypothesis, we: (1) systematically reviewed the literature for single nucleotide polymorphisms (SNPs) predisposing to type 2 diabetes in South Asians; (2) compared risk estimates, risk alleles and risk allele frequencies of predisposing SNPs between South Asians and white Europeans; and (3) tested the association of novel SNPs discovered from South Asians in white Europeans.
methodsMEDLINE, Embase, the Cumulative Index to Nursing and Allied Health Literature (CINAHL) and the Cochrane registry were searched for studies of genetic variants associated with type 2 diabetes in South Asians. Meta-analysis estimates for common and novel bi-allelic SNPs in South Asians were compared with white Europeans from the DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) consortium. The population burden from predisposing SNPs was assessed using a genotype score.
resultsTwenty-four SNPs from 21 loci were associated with type 2 diabetes in South Asians after meta-analysis. The majority of SNPs increase odds of the disorder by 15-35% per risk allele. No substantial differences appear to exist in risk estimates between South Asians and white Europeans from SNPs common to both groups, and the population burden also does not differ. Eight of the 24 are novel SNPs discovered from South Asian genome-wide association studies, some of which show nominal associations with type 2 diabetes in white Europeans. CONCLUSIONS/
interpretationBased on current literature there is no strong evidence to indicate that South Asians possess a greater genetic risk of type 2 diabetes than white Europeans.
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